UJI AKTIVITAS ANTIJAMUR DAUN AFRIKA (Vernonia amygdalina Dell.) TERHADAP JAMUR Trichophyton mentagrophytes = AFRICAN LEAF (Vernonia amygdalina Dell.) ANTIFUNGAL ACTIVITY TESTS AGAINTS THE FUNGUS Trichophyton mentagrophytes

Hehamahua, Amelia (2021) UJI AKTIVITAS ANTIJAMUR DAUN AFRIKA (Vernonia amygdalina Dell.) TERHADAP JAMUR Trichophyton mentagrophytes = AFRICAN LEAF (Vernonia amygdalina Dell.) ANTIFUNGAL ACTIVITY TESTS AGAINTS THE FUNGUS Trichophyton mentagrophytes. Diploma thesis, Universitas Pelita Harapan.

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Abstract

Jamur yang menyebabkan adanya infeksi pada kulit manusia yaitu pada jamur Trichophyton mentagrophytes. Pengobatan secara sintesis yang sering digunakan dalam pengobatan penyakit infeksi biasanya berupa obat terapi modern, akan tetapi obat tersebut mempunyai efek toksisitas yang menimbulkan efek samping yang tidak dinginkan bahkan bisa menimbulkan resistensi. Maka dari itu penggunaan daun Afrika (Vernonia amygdalina Dell.) secara empiris sering sekali digunakan oleh masyarakat dalam pengolahan yang sederhana dengan merebus daun Afrika (Vernonia amygdalina Dell.) lalu diminumnya. Penelitian ini merupakan penelitian menggunakan rancangan penelitian eksperimental disertai dengan studi literatur. Penelitian ini meliputi proses pada tahap preparasi (determinasi tanaman, pengambilan sampel, pembuatan simplisia, uji mutu simplisia) tahap ekstraksi, skrining fitokimia.. Hasil analisis yang didapatkan dari ekstrak daun Afrika (Vernonia amygdalina Dell.) mengandung senyawa aktif yaitu saponin, steroid, dan alkaloid. Senyawa aktif yang efektif berperan dalam daun Afrika (Vernonia amygdalina Dell.) yaitu saponin dikarenakan sifat saponin yang berasal dari suatu pembentukan ikatan senyawa polar saponin dengan lipoprotein dan ikatan gugus non polar dengan ikatan gugus sel jamur yang dapat menyebabkan permeabilitas membran sel jamur terganggu sehingga menyebabkan kematian pada jamur Trichophyton mentagrophytes. / The fungus that causes infection on human skin is the fungus Trichophyton mentagrophytes. Synthetic treatment that is often used in the treatment of infectious diseases is usually in the form of modern therapeutic drugs, but these drugs have toxic effects that cause unwanted side effects and can even cause resistance. Therefore, the use of African leaves (Vernonia amygdalina Dell.) empirically is often used by people in a simple processing by boiling African leaves (Vernonia amygdalina Dell.) and then drinking it. This research is a study using an experimental research design accompanied by a literature study. This research includes the process at the preparation stage (plant determination, sampling, making simplicia, simplicia quality test) extraction stage, phytochemical screening. The analysis results obtained from African leaf extract (Vernonia amygdalina Dell.) contain active compounds namely saponins, steroids, and alkaloids. The active compound that has an effective role in African leaves (Vernonia amygdalina Dell.) is saponins due to the nature of saponins derived from a bonding formation of polar saponins with lipoproteins and bonds of non-polar groups with fungalcell cluster bonds which can cause impaired fungal cell membrane permeability, causing death in the fungus Trichophyton mentagrophytes.

Item Type: Thesis (Diploma)
Creators:
CreatorsNIMEmail
Hehamahua, Amelia011741180002stevaniolin@gmail.com
Contributors:
ContributionContributorsNIDN/NIDKEmail
UNSPECIFIEDHardy, Junius0312067403junius.hardy@uph.edu
Uncontrolled Keywords: antijamur ; ekstrak ; daun Afrika (vernonia amygdalina Dell.)
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: University Subject > Current > Faculty/School - UPH Karawaci > Faculty of Health Sciences > Pharmacy (Diploma)
Current > Faculty/School - UPH Karawaci > Faculty of Health Sciences > Pharmacy (Diploma)
Depositing User: Users 6158 not found.
Date Deposited: 12 Feb 2022 13:08
Last Modified: 03 Mar 2022 23:03
URI: http://repository.uph.edu/id/eprint/45903

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