Perbandingan tingkat keparahan gejala pada pasien covid-19 antara yang belum dan sudah divaksin = Comparison of the severity of symptoms between unvaccinated and vaccinated covid-19 patients

Patricia, Mika (2022) Perbandingan tingkat keparahan gejala pada pasien covid-19 antara yang belum dan sudah divaksin = Comparison of the severity of symptoms between unvaccinated and vaccinated covid-19 patients. Bachelor thesis, Universitas Pelita Harapan.

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Abstract

Vaksinasi COVID-19 masih terus dilakukan pada berbagai negara termasuk Indonesia untuk menanggulangi pandemi COVID-19. Beberapa penelitian tentang efikasi dan dampak vaksin dalam menurunkan penularan, hasil klinis yang buruk, dan kematian telah dilakukan di beberapa negara, namun hasil penelitian menunjukkan hasil yang berbeda-beda. Data mengenai hubungan vaksinasi dengan tingkat keparahan gejala COVID-19 masih kurang terutama di Indonesia. Penelitian ini dilakukan untuk mengetahui perbandingan tingkat keparahan gejala COVID-19 pada pasien yang belum dan sudah divaksin di Indonesia. Tujuan penelitian ini yaitu membandingkan tingkat keparahan gejala pada pasien COVID-19 yang belum dan sudah divaksin. Penelitian ini merupakan studi analitik potong lintang dengan metode analitik komparatif kategorik tidak berpasangan. Data sekunder diambil dari rekam medis pasien COVID-19 di Puskesmas Tegal Angus Kabupaten Tangerang dari Januari sampai Desember 2021, kemudian sampel dipilih dengan cara pengambilan sampel acak sederhana. Data vaksin pasien yang terpilih dicari di registrasi P-care. Data yang diperoleh akan dimasukkan ke formulir pengambilan data. Analisis data menggunakan metode Chi Square dan multivariat regresi logistik. Orang yang belum divaksin probabilitasnya lebih besar untuk mengalami COVID-19 dengan tingkat keparahan gejala sedang dan berat dibanding yang sudah divaksin dengan masing-masing nilai OR 4.148 (95%CI 1.148-14.995; p value 0.026) dan 26.00 (95%CI 2.451-27.582; p value 0.002). Status vaksin memiliki hubungan yang signifikan dengan tingkat keparahan gejala sedang dan berat, tetapi tidak berhubungan dengan tingkat keparahan gejala ringan. / COVID-19 vaccination are still being continued in various countries including Indonesia to overcome the COVID-19 pandemic. Several studies about the efficacy and impact of vaccines in reducing transmission, poor clinical outcomes, and mortality have been done in several countries, but the results of these studies show different results. Data about the relationship between vaccination and the severity of COVID-19 symptoms is still lack, especially in Indonesia. This study is to compare the severity of COVID-19 symptoms between unvaccinated and vaccinated COVID-19 patients. The purpose to this research is to compare the severity of symptoms in unvaccinated and vaccinated COVID-19 patients. This research is a cross-sectional study using unpaired categorical comparative analytical method. Secondary data is taken from the medical records of COVID-19 patients at Tegal Angus Public Health Center, Tangerang District from January to December 2021, sample will be selected by simple random sampling. Vaccine data of selected patients will be searched in the P-care registration. Data will be entered into form. Data analysis using Chi Square method and multivariate logistic regression. People who have not been vaccinated have a greater probability of experiencing COVID-19 with moderate and severe symptom that those who have been vaccinated with each OR 4.148 (95%CI 1.148-14.995; p value 0.026) and 26.00 (95%CI 2.451-27.582; p value 0.002). Vaccine status had a significant relationship with moderate and severe symptom, but not associated with mild symptom.

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