Hubungan antara aspek klinikopatologi dengan ekspresi pdl-1 pada karsinoma paru bukan sel kecil

Siahaya, Agnes (2022) Hubungan antara aspek klinikopatologi dengan ekspresi pdl-1 pada karsinoma paru bukan sel kecil. Bachelor thesis, Universitas Pelita Harapan.

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Abstract

Latar Belakang: Karsinoma Paru Bukan Sel Kecil atau disingkat sebagai Non Small Cell Lung Carcinoma (NSCLC) merupakan penyebab kematian utama yang berhubungan dengan keganasan, khususnya di Asia. NSCLC disebabkan oleh merokok sebagai faktor risiko utama dan umur, jenis kelamin serta genetik sebagai faktor risiko lainnya. Kumpulan faktor risiko tersebut menjadi aspek klinikopatologi terhadap ekspresi Programmed Death Ligand – 1 (PD L-1) pada pasien dengan NSCLC. Menurut Xirong Fan, dkk. hanya aspek histologi dan stadium kanker pada pasien yang paling berpengaruh terhadap ekspresi PD-L1 positif. Maka, penelitian ini dilakukan untuk melihat hubungan aspek klinikopatologi lain yang mempengaruhi ekspresi PD-L1. Tujuan Penelitian: Penelitian ini bertujuan untuk melihat adanya hubungan antara aspek klinikopatologi dengan ekspresi PD L-1 pada pasien dengan NSCLC. Metode: Penelitian ini dilakukan dengan studi cross-sectional. Data yang diambil merupakan data sekunder dari Rumah Sakit MRCCC Siloam melalui metode purposive sampling. Data telah dikumpulkan dan dianalisis menggunakan SPSS 25.0. Hasil: Ekspresi PDL-1 positif terlihat pada 42,2% dari keseluruhan 97 data rekam medis yang diambil. Mayoritas data merupakan laki-laki (62,8%) dengan rentang usia 34-83 tahun. Subtipe tumor terbanyak dari data yaitu adenokarsinoma (77,3%) yang berasal dari paru kanan (56,8%). Kesimpulan: Dari hasil analisis data dan temuan penelitian, maka dapat disimpulkan bahwa aspek klinikopatologi umur, jenis kelamin, letak tumor dan subtipe kanker tidak berhubungan dengan ekspresi PDL-1 pada karsinoma paru bukan sel kecil. Kata Kunci: klinikopatologi, ekspresi PD L-1, karsinoma paru, kpbsk / Background: Non-Small Cell Lung Carcinoma or abbreviated as Non-Small Cell Lung Carcinoma (NSCLC) is the leading cause of death related to malignancy, especially in Asia. NSCLC is caused by smoking as the main risk factor and age, sex and genetics as other risk factors. The collection of these risk factors is a clinicopathological aspect of the expression of Programmed Death Ligand-1 (PD L-1) in patients with NSCLC. According to Xirong Fan, dkk. only the histological aspect and cancer stage in the patient had the most influence on the positive PD-L1 expression. Thus, this study was conducted to examine the relationship of other clinicopathological aspects that affect the expression of PD-L1. Research Objectives: This study aimed to examine the relationship between clinicopathological aspects and PD L-1 expression in patients with NSCLC. Methods: This study was conducted with a cross-sectional study. The data taken is secondary data from MRCCC Siloam Hospital through purposive sampling method. Data have been collected and analyzed using SPSS 25.0. Results: Positive PDL-1 expression was seen in 42.2% of all 97 medical record data taken. The majority of the data are male (62.8%) with an age range of 34-83 years. The most tumor subtype from the data was adenocarcinoma (77.3%) originating from the right lung (56.8%). Conclusion: From the results of data analysis and research findings, it can be concluded that the clinicopathological aspects of age, gender, tumor location and cancer subtype are not associated with PDL-1 expression in non-small cell lung carcinoma. Keyword: lung carcinoma, nsclc, clinicopathology, PD L-1 expression

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