Hubungan kejadian ikutan dan derajat keparahan kejadian ikutan terhadap autoimunitas serta angka kekambuhan autoimun pada perempuan pasca vaksinasi coronavac

Haryanto, Maria Aurelia (2022) Hubungan kejadian ikutan dan derajat keparahan kejadian ikutan terhadap autoimunitas serta angka kekambuhan autoimun pada perempuan pasca vaksinasi coronavac. Bachelor thesis, Universitas Pelita Harapan.

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Abstract

Pendahuluan: Kejadian ikutan pasca imunisasi (KIPI) pada penerima vaksin Covid-19 yang salah satunya adalah CoronaVac merupakan salah satu pertimbangan penting dalam pemberian vaksin, terutama pada kelompok khusus seperti pada pasien dengan autoimunitas (ODAI). Penelitian ini bertujuan untuk mengetahui perbandingan angka KIPI CoronaVac pada ODAI dan orang tanpa autoimunitas (OTAI) pada perempuan. Metode: Penelitian ini merupakan penelitian cohort retrospective, dengan desain penelitian analitik komparatif tidak berpasangan, dengan total 602 sampel, yang terdiri dari 182 ODAI dan 420 OTAI, kriteria inklusi sample penelitian adalah perempuan yang menerima vaksin CoronaVac, usia 17-65 tahun, dan memiliki ras mongoloid. pengambilan sampel dilakukan dengan simple random sampling. Data dianalisis menggunakan metode chi-square atau fisher exact sebagai alternatif. Hasil: Berdasarkan hasil analisis bivariat Chi Square ditemukan KIPI (p=0.007, RR= 1.179 95% CI 1.059 – 1.313), KIPI Sistemik (p= 0.025, RR= 1.1271 95% CI 1.045 – 1.545), KIPI alergi (p= 0.045, RR= 2.052 95% CI 1.070 – 3.932), KIPI demam (p= 0.039, RR= 2.163 95% CI 1.093 – 4.282), KIPI kelelahan (p= 0.001, RR= 2.182 95% CI 1.558 – 3.056), KIPI sakit kepala (p= 0.006, RR= 1.619 95% CI 1.164 – 2.251) memiliki hubungan yang signifikan dengan autoimunitas. Hubungan tidak signifikan ditemukan antara autoimunitas dengan KIPI lokal (p= 0.076, RR= 1.153 95% CI 0.998 – 1.335), KIPI bengkak dan kemerahan (p= 0.070, RR= 0.737 95% CI 0.535 – 1.016), KIPI nyeri dan pegal (p= 0.158, RR= 1.128 95% CI 0.968 – 1.315), KIPI mual/muntah (p= 0.522, RR= 1.273 95% CI 0.709 –2.286, RR= 1.385 95% CI 0.748 – 2.564), KIPI nyeri ulu hati/diare (p= 0.391, RR= 1.385 95% CI 0.748 – 2.564), KIPI mengantuk (p= 0.075, RR= 0.659 95% CI 0.424 – 1.025), KIPI nafsu makan meningkat (p= 0.800, RR= 1.231 95% CI 0.531 –2.852), dan derajat keparahan KIPI secara keseluruhan (p= 0.256, RR= 0.851 95% CI (0.655) – 1.105). kekambuhan autoimun pascavaksinasi CoronaVac adalah 19 (10,4%) orang. Diskusi: Terdapat hubungan yang signifikan antara status autoimunitas dan kejadian ikutan pascavaksinasi CoronaVac./Introduction: Post-exercise follow-up events (AEFI) in the Covid-19 vaccine, one of which is CoronaVac, is one of the important considerations in administering vaccines, especially in special groups such as patients with autoimmunity (ODAI). This study aims to compare the number of CoronaVac AEFIs in ODAI and people without autoimmunity (OTAI) in women. Methods: This study is a retrospective cohort study, with an unpaired comparative analytic study design, with total 602 samples which consists of 182 ODAI and 420 OTAI, the inclusion criteria of the study sample were women who received CoronaVac vaccine, aged 17-65 years, and had Mongolian race. Sampling was done by simple random sampling. Data were analyzed using the chi-square or fisher exact method as an alternative. Result: Based on the results of the Chi Square bivariate analysis found AEFI (p=0.007, RR= 1.179 95% CI 1.059 – 1.313), Systemic AEFI (p= 0.025, RR= 1.1271 95% CI 1.045 – 1.545), allergic AEFI (p= 0.045, RR = 2.052 95% CI 1.070 – 3.932), AEFI of fever (p= 0.039, RR= 2.163 95% CI 1.093 – 4.282), AEFI of fatigue (p= 0.001, RR= 2.182 95% CI 1.558 – 3.056), headache AEFI ( p= 0.006, RR= 1.619 95% CI 1.164 – 2.251) had a significant relationship with autoimmunity. No significant association was found between autoimmunity and local AEFI (p= 0.076, RR= 1.153 95% CI 0.998 – 1.335), AEFI swelling and redness (p= 0.070, RR= 0.737 95% CI 0.535 – 1.016), AEFI pain and aches ( p= 0.158, RR= 1.128 95% CI 0.968 – 1.315), AEFI nausea/vomiting (p= 0.522, RR= 1.273 95% CI 0.709 – 2.286, RR= 1.385 95% CI 0.748 – 2.564), AEFI heartburn/ diarrhea (p= 0.391, RR= 1.385 95% CI 0.748 – 2.564), sleepiness AEFI (p= 0.075,RR= 0.659 95% CI 0.424 – 1.025), increased appetite AEFI (p= 0.800, RR= 1.231 95% CI) 0.531 – 2.852), and the overall severity of AEFI (p= 0.256, RR= 0.851 95% CI (0.655) – 1.105). autoimmune recurrence after CoronaVac vaccination was 19 (10.4%) people. Discussion: There is a significant relationship between autoimmunity status and co-occurrence after CoronaVac vaccination.

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