Uji potensi tabir surya pada ekstrak daun bangun-bangun (Coleus amboinicus Lour.) secara in vitro

Lodwinia, Margaretha (2023) Uji potensi tabir surya pada ekstrak daun bangun-bangun (Coleus amboinicus Lour.) secara in vitro. Bachelor thesis, Universitas Pelita Harapan.

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Abstract

Terpaparnya sinar matahari secara berlebihan dalam waktu yang lama dapat menyebabkan bagian jaringan di epidermis kulit tidak dapat melawan efek negatif akut atau kronis. Penggunaan tabir surya adalah cara dalam meminimalisir timbulnya bahaya pada kulit. Ekstrak daun bangun-bangun dapat dijadikan sebagai tabir surya karena terdapat kandungan fenol atau flavonoid yang dapat menangkal radikal induksi ultraviolet (UV) dan memberikan perlindungan dari sinar UV. Pengujian dilakukan dengan ekstraksi dengan metode maserasi dengan pelarut bertingkat n-heksana, etil asetat dan etanol 70%. Ekstrak yang telah memenuhi standar dilakukan pengujian fenolik total, flavonoid total, persentase eritema dan pigmentasi serta nilai SPF (Sun Protection Factor). Penelitian ini dilakukan dengan menggunakan instrumen Spektrofotometer UV-Vis. Ekstrak daun bangun-bangun memiliki metabolit sekunder yaitu flavonoid dan fenolik Kandungan metabolit sekunder mendukung ekstrak n-heksana dalam meningkatkan nilai Sun Protection Factor. Hasil ekstrak etil asetat memberikan proteksi ultra dengan berdasarkan nilai Sun Protection Factor yaitu 37,71 dan dapat dijadikan sebagai sunblock berdasarkan nilai transmisi eritema yaitu 0,015 serta nilai transmisi pigmentasi yaitu 0,02. Kadar flavonoid total tertinggi terdapat pada ekstrak etil asetat sebanyak 1299,83 mgQE/100gr dan kadar fenolik total tertinggi terdapat pada ekstrak etanol 70% sebanyak 259,89 mgQE/100gr. / Excessive exposure to sunlight for a long time can cause the tissue in the epidermis of the skin to be unable to fight against acute or chronic negative effects. The use of sunscreen is a way to minimize the appearance of harm to the skin. Bangun- Bangun leaf extract can be used as a sunscreen because it contains phenol or flavonoids which can counteract ultraviolet (UV)-induced radicals and provide protection from UV rays. Tests were carried out by extraction using the maceration method with n-hexane, ethyl acetate and 70% ethanol as solvents. Extracts that met the standards were tested for total phenolics, total flavonoids,percentage erythema and pigmentation as well as the SPF value (Sun Protection factor). This research was conducted using instrument UV-Vis Spectrophotometer. Bangun- Bangun leaf extract has secondary metabolites, namely flavonoids and phenolics. The content of secondary metabolites supports the n-hexane extract in increasing valueSun Protection Factor. The results of the ethyl acetate extract provide ultra protection based on valueSun Protection Factor which is 37.71 and can be used as a sunblock based on the erythema transmission value of 0.015 and the pigmentation transmission value of 0.02. The highest total flavonoid content was found in the ethyl acetate extract of 1299.83 mgQE/100gr and the highest total phenolic content was found in the 70% ethanol extract of 259.89 mgQE/100gr.

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