Hubungan antara faktor klinis terhadap faktor patologis pada pasien karsinoma payudara invasif di Rumah Sakit Siloam Karawaci Gedung B tahun 2021-2022 = Relationship between clinical factors and pathological factors in invasting breast carcinoma patients at Siloam Hospital Karawaci Building B in 2021-2022

Hidayani, Intan (2023) Hubungan antara faktor klinis terhadap faktor patologis pada pasien karsinoma payudara invasif di Rumah Sakit Siloam Karawaci Gedung B tahun 2021-2022 = Relationship between clinical factors and pathological factors in invasting breast carcinoma patients at Siloam Hospital Karawaci Building B in 2021-2022. Bachelor thesis, Universitas Pelita Harapan.

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Abstract

Latar Belakang: Berdasarkan data Kementerian Kesehatan Republik Indonesia (Kemenkes) dipublikasikan pada 2 Februari 2022 dinyatakan bahwa kanker payudara menjadi salah satu penyebab kematian akibat kanker dengan urutan pertama di Indonesia. Menurut data World Health Organization (WHO) dari Global Cancer Observatory (GCO) tahun 2018 terdapat 58.256 kasus atau 16,7% dari seluruh kasus kanker payudara dilaporkan di Indonesia. Beberapa tahun terakhir ini penelitian mengenai hubungan antara faktor klinis terhadap faktor patologis pada pasien karsinoma payudara invasif berdasarkan World Health Organization (WHO) edisi terbaru tahun 2019 masih terbatas. Tujuan Penelitian: Penelitian ini bertujuan untuk mengetahui hubungan antara faktor klinis yaitu usia, jenis kelamin, indeks massa tubuh, riwayat menyusui, dan riwayat keluarga terhadap faktor patologis yaitu subtipe histopatologi, derajat histopatologi, stage dan subtipe molekuler pada pasien karsinoma payudara invasif di Rumah Sakit Siloam Karawaci Gedung B pada tahun 2021-2022. Metode Penelitian: Penelitian ini menggunakan metode cross-sectional yang dilakukan pada pasien karsinoma payudara invasif di Rumah Sakit Siloam Karawaci Gedung B pada tahun 2021-2022 yang memenuhi kriteria dalam penelitian. Data dalam penelitian ini didapatkan dari hasil pemeriksaan histopatologi, pemeriksaan imunohistokimia, Nottingham Grading System pada rekam medis di Rumah Sakit Siloam Karawaci. Hasil: Hasil data terbanyak pada pasien perempuan dengan usia lebih dari 50 tahun, indeks massa tubuh normal, terdapat riwayat menyusui, tidak terdapat/tidak diketahui riwayat keluarga, subtipe non-special type (NST), derajat 2, stadium awal, subtipe molekuler luminal. Kesimpulan: Terdapat hubungan yang signifikan antara faktor klinis usia terhadap faktor patologis stage & subtipe molekuler, tidak terdapat hubungan yang signifikan antara faktor klinis usia terhadap faktor patologis subtipe histopatologi & derajat histopatologi dan tidak terdapat hubbungan yang signifikan antara faktor klinis jenis kelamin, indeks massa tubuh (IMT), riwayat menyusui & Riwayat keluarga terhadap faktor patologis subtipe histopatologi, derajat histopatologi, stage & subtipe molekuler di Rumah Sakit Siloam Karawaci Gedung B tahun 2021-2022. /Background: Based on data from the Ministry of Health of the Republic of Indonesia (Kemenkes) published on February 2, 2022, it is stated that breast cancer is one of the leading causes of cancer death in Indonesia. According to World Health Organization (WHO) data from the Global Cancer Observatory (GCO) in 2018, there were 58,256 cases or 16.7% of all breast cancer cases reported in Indonesia. In recent years, research on the relationship between clinical factors and pathological factors in invasive carcinoma patients based on the new edition of the World Health Organization (WHO) in 2019 is still limited. Objective: This study aims to determine the relationship between clinical factors, namely age, gender, body mass index, breastfeeding history, and family history of pathological factors, namely histopathological subtype, histopathological degree, stage and molecular subtype in patients with invasive carcinoma at Siloam Hospital Karawaci in 2021-2022. Hypothesis: there is a relationship between clinical factors and pathological factors in invasive carcinoma patients at Siloam Karawaci Hospital in 2021-2022. Methods: This study used a cross-sectional method which was carried out on invasive carcinoma patients at Siloam Karawaci Hospital in 2021-2022 who met the criteria in the study. The data in this study were obtained from the results of histopathological examination, immunohistochemical examination, Nottingham Grading System on medical records at Siloam Karawaci Hospital. Results: Most data were found in female patients over 50 years of age, normal body mass index, history of breastfeeding, no/no family history, non-special type (NST) subtype, grade 2, early stage, luminal molecular subtype . Conclusion: There is a significant relationship between clinical age and pathological stage & molecular subtypes, there is no significant relationship between clinical age and pathological factors histopathological subtype & histopathological degree and there is no significant relationship between clinical factors gender, body mass index (BMI), history of breastfeeding & family history of pathological factors, histopathological subtype, histopathological degree, stage & molecular subtype at Siloam Hospital Karawaci Building B in 2021-2022.

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