Hubungan serotipe virus dengue dengan hari awitan dan hasil hematologi sederhana pada pasien infeksi dengue di rumah sakit pendidikan Siloam = Correlation of dengue serotype with days of onset and basic hematological results of dengue patients in Siloam teaching hospital

Maulidia, Syafna Azrianindita (2023) Hubungan serotipe virus dengue dengan hari awitan dan hasil hematologi sederhana pada pasien infeksi dengue di rumah sakit pendidikan Siloam = Correlation of dengue serotype with days of onset and basic hematological results of dengue patients in Siloam teaching hospital. Bachelor thesis, Universitas Pelita Harapan.

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Abstract

Latar Belakang: Infeksi dengue yang disebabkan oleh minimal satu serotipe DENV merupakan salah satu penyakit tropis dengan insiden yang meningkat setiap tahunnya. Pengelolaan yang salah akan membebani sistem pelayanan kesehatan. Literatur dan penelitian mengenai hubungan antara serotipe virus dengue dengan hari awitan dan hasil hematologi pasien dengue masih minimal sehingga diperlukan penelusuran lebih lanjut untuk mengurangi beban sistem pelayanan kesehatan. Tujuan Penelitian: Penelitian ini dilakukan untuk mengetahui hubungan antara serotipe virus dengue dengan hari awitan dan hasil hematologi sederhana pada pasien infeksi dengue di Rumah Sakit Pendidikan Siloam. Hipotesis: Terdapat hubungan antara serotipe virus dengue dengan hari awitan dan hasil hematologi sederhana pada pasien infeksi dengue di Rumah Sakit Pendidikan Siloam. Metode Penelitian: Studi potong-lintang dengan total sampel 104 akan dilakukan dengan purposive sampling dari database pasien infeksi dengue Rumah Sakit Pendidikan Siloam tahun 2019-2020, uji normalitas Kolmogorov-Smirnov akan dilakukan sebelum uji ANOVA/Kruskal Wallis. Hasil: Uji hipotesis menunjukkan bahwa serotipe virus dengue memiliki hubugan yang signifikan dengan hari awitan dan persentase limfosit (p=0,010). Rata-rata hari awitan tertinggi dapat terlihat pada DENV-1 (3,25±0,93 hari) dan infeksi dengan 2 serotipe (3,25±0,87 hari). Persentase limfosit tertinggi terlihat pada infeksi dengan 2 serotipe (35,58±19,10%). Kesimpulan: Terdapat hubungan antara serotipe virus dengue dengan hari awitan dan persentase limfosit. / Background: Dengue is a tropical disease caused by at least one DENV serotype which incidence increasing annually. Mismanagement of disease will be a burden to health care system. Number of literature and research regarding correlation between dengue serotypes, days of onset, and basic hematological results still low, further research are expected to reduce probability of impact on health care system. Aim: This study aims to determine the correlation between dengue serotypes, days of onset, and basic hematological results in patients with dengue infection in Siloam Teaching Hospital. Hypothesis: There is a correlation between dengue serotype with days of onset and basic hematological results of dengue patients in Siloam Teaching Hospital. Methods: Cross-sectional study with a total sample of 104 will be conducted by purposive sampling from Siloam Teaching Hospital database of dengue infection patients in 2019-2020, Kolmogorov-Smirnov normality test will be performed prior to ANOVA/Kruskal Wallis test. Result: The hypothesis test showed that dengue serotype correlated significantly with days of onset and percentage of lymphocytes (p=0,010). The mean value of days of onset was highest on DENV-1 patients (3,25±0,93 days) and patients with mixed infection (3,25±0,87 days). Highest percentage of lymphocytes was seen on on mixed infection patients (35,58±19,10%). Conclusion: There is a correlation between dengue serotype with days of onset and percentage of lymphocyte.

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