Karakteristik pasien spasme hemifasial yang diterapi injeksi toksin botolinum di Siloam Hospitals Lippo Village Gedung B

Nunuhitu, Wihelmina (2023) Karakteristik pasien spasme hemifasial yang diterapi injeksi toksin botolinum di Siloam Hospitals Lippo Village Gedung B. Bachelor thesis, Universitas Pelita Harapan.

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Abstract

Spasme hemifasial merupakan kelainan gerakan kontraksi involunter pada otot wajah yang terjadi pada kurang lebih 9 – 11 orang dari 100.000 populasi. Kelainan ini merupakan kelainan yang tergolong jarang ditemukan di lapangan. Gejala yang timbul pada kelainan ini adalah kedutan yang secara tiba-tiba muncul dan tidak bisa dihentikan atau tidak bisa dikontrol. Walaupun sesuai jurnal-jurnal yang ada, kelainan ini tergolong penyakit yang jarang ditemukan, kelainan ini tetap memiliki pengaruh bagi penderitanya. Umumnya, kelainan ini memang tidak menyebabkan rasa sakit tetapi gejala yang muncul bisa sangat menggangu kegiatan penderita sehari-hari. Beberapa pasien mengalami rasa malu jika mengalami kedutan tiba-tiba saat aktifitas sosial dan ada beberapa juga yang memilih untuk mengurung diri dan kelainan ini meningkatkan kelainan depresi di beberapa individu. Toksin botulinum merupakan neurotoxin yang dihasilkan oleh bakteri Clostridium botulinum. Toksin botulinum atau BoNT bekerja dengan cara menghambat pelepasan neurotransmitter ke celah sinaps sehingga tidak terjadi kontraksi dari otot. Karena kemampuannya untuk menyebabkan paralisis dari otot, BoNT menjadi salah satu pilihan untuk terapi spasme hemifasial. / Hemifacial spasm is an involuntary movement disorder of the facial muscles that happens to 9-11 out of 100.000 population in the world. It is considered a rare disease in the field. The symptoms that arise in this disorder are twitches that suddenly appear and cannot be stopped or controlled. Although hemifacial spasm is considered rare, it still has some impacts for its sufferer. Generally, this disorder does not cause any pain, but the symptoms that appear can greatly interfere with sufferer’s daily activities. Some patient experience embarrassment when they experience these sudden twitches during social activities and some choose to withdraw themselves from their social live. That is why this disorder could increase the tendency to develop depression in some individuals. Botulinum toxin or BoNT works by inhibiting the release of neurotransmitter into the synaptic gap making no contraction no muscle. Because of its ability to cause muscle paralysis, BoNT is one of the option for hemifacial spasm therapy.

Item Type: Thesis (Bachelor)
Creators:
CreatorsNIMEmail
Nunuhitu, WihelminaNIM01071200147nunuhituwihelmina@gmail.com
Contributors:
ContributionContributorsNIDN/NIDKEmail
Thesis advisorKetaren, RetnoNIDN0307038301retno.ketaren@uph.edu
Uncontrolled Keywords: spasme hemifasial; toksin botolinum; hemifacial spasm; botulinum toxin
Subjects: R Medicine > R Medicine (General)
Divisions: University Subject > Current > Faculty/School - UPH Karawaci > Faculty of Medicine > Medicine
Current > Faculty/School - UPH Karawaci > Faculty of Medicine > Medicine
Depositing User: Wihelmina Burhandiah
Date Deposited: 04 Jan 2024 01:37
Last Modified: 04 Jan 2024 01:37
URI: http://repository.uph.edu/id/eprint/59630

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