Hubungan antara faktor klinis-patologis dengan ekspresi gen ALK pada karsinoma paru bukan sel kecil di RS MRCCC Siloam Semanggi pada tahun 2020-2022 = Relationship between clinical-pathological factors and ALK gene expression in non-small cell lung carcinoma at MRCCC Siloam Semanggi Hospital in 2020 - 2022

Sumbayak, Ester Elita (2023) Hubungan antara faktor klinis-patologis dengan ekspresi gen ALK pada karsinoma paru bukan sel kecil di RS MRCCC Siloam Semanggi pada tahun 2020-2022 = Relationship between clinical-pathological factors and ALK gene expression in non-small cell lung carcinoma at MRCCC Siloam Semanggi Hospital in 2020 - 2022. Bachelor thesis, Universitas Pelita Harapan.

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Abstract

Latar Belakang: Kanker paru adalah penyakit pertumbuhan jaringan yang tidak dapat terkontrol pada jaringan paru. Kanker paru menyebabkan 2.200.000 kasus baru, dan 1.800.000 kasus kematian. Secara patogenesis, pertumbuhan kanker paru dipengaruhi oleh berbagai mutasi gen, salah satunya adalah ALK. Jika terjadi rearrangement pada ekspresi ALK, akan menyebabkan poliferasi onkogen dari sel kanker paru-paru. Ekspresi gen ALK dikaitkan dengan faktor klinikopatologi untuk memperjelas karakteristik klinikopatologi pasien kanker paru, yang mengalami rearrangement pada ekspresi ALK. Tujuan Penelitian: Tujuan penelitian ini adalah meneliti hubungan faktor klinikopatologi dengan ekspresi ALK pada Karsinoma Paru Bukan Sel Kecil di RS MRCCC Siloam, Semanggi Metode Penelitian: Penelitian ini menggunakan data sekunder berupa rekam medis dari RS MRCCC Siloam Semanggi dari tahun 2020 sampai 2022. Data akan dianalisis secara bivariat menggunakan uji Chi Square menggunakan program SPSS versi 26.0. Hasil Penelitian Jenis kelamin pasien paling banyak pada laki-laki, dengan jumlah 79 orang (63.2%). Usia pasien pada usia < 60 tahun terdapat 48 orang (38.4%). Lokasi tumor pada pasien paling banyak di paru-paru kanan dengan jumlah 70 orang (56%). Morfologi Tumor paling banyak adalah jenis adenokarsinoma 96 orang (76.8%). Setelah melakukan pemeriksaan ekspresi ALK, 117 orang (93.6%) menunjukkan hasil negatif sedangkan 8 orang (6.4%) menunjukkan hasil positif. Kesimpulan: Hubungan antara faktor klinikopatologi dan ekspresi ALK pada kanker paru sel kecil tidak menunjukkan hasil yang signifikan / Background: Lung cancer is a disease of uncontrolled growth of tissue in the lung tissue. In 2020, lung cancer causes 2,200,000 new cases and 1,800,000 deaths. In pathogenesis, the growth of lung cancer is influenced by various gene mutations, one of which is the ALK gene. If there is a rearrangement in ALK expression, it will cause oncogene proliferation of lung cancer cells. Expression of ALK gene is associated with clinicopathological factors to clarify the clinicopathological characteristics of lung cancer patients, who experience a rearrangement in ALK expression. Aim: The purpose of this study was to determine the relationship between clinicopathological factors and ALK expression in Non-Small Cell Lung Carcinoma at MRCCC Siloam Hospital, Semanggi. Methods: This study uses secondary data in the form of medical records from the MRCCC Siloam Semanggi Hospital from 2020 to 2022. The data will then be analysed bivariate using the Chi Square test using SPSS version 26.0. Result: The gender of most patients was male, with a total of 79 people (63.2%). There were 48 patients aged <60 years (38.4%). The tumour location in most patients was in the right lung with a total of 70 people (56%). The most common tumour morphology was adenocarcinoma in 96 people (76.8%). After examining ALK expression, 117 people (93.6%) showed negative results while 8 people (6.4%) showed positive results. Conclusion: The relationship between clinicopathological factors and ALK expression in small cell lung cancer did not show significant results

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