Hubungan antara Aspek Klinikopatologi Kanker Kolorektal dengan Ekspresi Mutasi Gen KRAS di RS MRCCC Siloam Semanggi dari Tahun 2020-2022

Agustin, Jestin (2023) Hubungan antara Aspek Klinikopatologi Kanker Kolorektal dengan Ekspresi Mutasi Gen KRAS di RS MRCCC Siloam Semanggi dari Tahun 2020-2022. Bachelor thesis, Universitas Pelita Harapan.

Preview	Text (Title) Title.pdf Available under License Creative Commons Attribution Non-commercial Share Alike. Download (181kB) | Preview
Preview	Text Abstract.pdf Available under License Creative Commons Attribution Non-commercial Share Alike. Download (232kB) | Preview
Preview	Text ToC.pdf Available under License Creative Commons Attribution Non-commercial Share Alike. Download (245kB) | Preview
Preview	Text Chapter 1.pdf Available under License Creative Commons Attribution Non-commercial Share Alike. Download (206kB) | Preview
	Text Chapter 2.pdf Restricted to Registered users only Available under License Creative Commons Attribution Non-commercial Share Alike. Download (18MB)
	Text Chapter 3.pdf Restricted to Registered users only Available under License Creative Commons Attribution Non-commercial Share Alike. Download (243kB)
Preview	Text Chapter 5.pdf Available under License Creative Commons Attribution Non-commercial Share Alike. Download (263kB) | Preview
	Text Chapter 6.pdf Restricted to Registered users only Available under License Creative Commons Attribution Non-commercial Share Alike. Download (178kB)
Preview	Text Bibliography.pdf Available under License Creative Commons Attribution Non-commercial Share Alike. Download (94kB) | Preview
	Text Appendices.pdf Restricted to Repository staff only Available under License Creative Commons Attribution Non-commercial Share Alike. Download (4MB)
	Text Chapter 4.pdf Restricted to Registered users only Available under License Creative Commons Attribution Non-commercial Share Alike. Download (252kB)

Abstract

Latar belakang: Kanker kolorektal merupakan salah satu penyakit yang menyumbang mortalitas dan morbiditas terbanyak di Indonesia. Mutasi gen KRAS merupakan salah satu penyebab dari kanker kolorektal. Data mengenai hubungan aspek klinikopatologi dengan ekspresi mutasi gen KRAS masih sedikit dan menunjukkan hasil yang tidak konsisten. Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan antara aspek klinikopatologi dengan ekspresi mutasi gen KRAS di RS MRCCC Siloam Semanggi. Metode: Penelitian ini menggunakan metode studi potong lintang dengan jenis penelitian analitik komparatif kategorik tidak berpasangan. Besar sampel sebesar 134 pasien kanker kolorektal diambil dari data rekam medis di Rumah Sakit MRCCC Siloam Semanggi pada tahun 2020-2022. Uji statistik akan diolah menggunakan program SPSS 26.0 menggunakan metode Chi Square. Hasil: Hasil penelitian menunjukkan bahwa dari 90 sampel terdapat 37 (41%) pasien kanker kolorektal yang memiliki ekpresi mutasi gen KRAS. Mutasi gen KRAS lebih banyak terjadi pada laki-laki, usia diatas 50 tahun, lokasi terbanyak di kolon, serta tumor berdiferensiasi baik. Kesimpulan: Tidak terdapat hubungan yang signifikan antara aspek klinikopatologi kanker kolorektal dengan ekspresi mutasi gen KRAS (OR = 0,556 ; 95% CI = 0,234- 1,321 ; p-value = 0,182). / Background: Colorectal carcinoma is a disease that causes the most mortality and morbidity in Indonesia. KRAS gene mutation is one of the causes of colorectal cancer. There are only a few data regarding the relationship between clinicopathological aspects and KRAS mutation expression in colorectal cancer and shows inconsistent result. Objetive: This study aims to determine the relationship between clinicopathological aspects and the expression of KRAS gene mutations at the MRCCC Siloam Semanggi Hospital. Method: : This study uses a cross-sectional study method which is categorized as an unpaired categorical comparative analytical study. The sample size in this study is the 134 colorectal cancer patients who were taken through medical record data at the MRCCC Siloam Semanggi Hospital in 2020-2022. The statistical test will be processed by the SPSS 26.0 program using the Chi Square method. Results: The results showed that from 90 samples there were 37 (41%) colorectal cancer patients who expressed KRAS gene mutations. KRAS gene mutations occur more often in men, aged over 50 years, most commonly located in the colon, and well- differentiated tumors. Conclusion: There is no significant relationship between the clinicopathology of colorectal cancer and the expression of KRAS gene mutations (OR = 0.556; 95% CI = 0.234-1.321; p-value = 0.182).

Actions (login required)

View Item