Hubungan subtipe stroke terhadap insidensi kejang pasca stroke pada pasien di Rumah Sakit Siloam Karawaci = The relation of stroke subtypes to post-stroke seizure incidence on patients in Siloam Hospital Karawaci

Raintama, Brillyant Sabatino (2018) Hubungan subtipe stroke terhadap insidensi kejang pasca stroke pada pasien di Rumah Sakit Siloam Karawaci = The relation of stroke subtypes to post-stroke seizure incidence on patients in Siloam Hospital Karawaci. Bachelor thesis, Universitas Pelita Harapan.

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Abstract

Background Stroke is a cerebrovascular disease causing 113,000,000 disability and 6,500,000 mortality. Seizure occurred on 12% stroke patients. In Indonesia, stroke counts as 12.1% of all diseases with 15.4% mortality rate. 80% of stroke patients come from developing countries, like Indonesia. Study shows that post-stroke seizures have worse prognosis than one without. Furthermore, studies revealed that hemorrhagic stroke is riskier in developing seizure (4.3 – 24%) than ischemic (2 – 13.5%). Purpose This study aims to understand the stroke subtype relations toward seizure. Research method On February to April 2018, this cross-sectional study was done in the Siloam Hospital Medical Record, Karawaci. 190 samples are chosen by purposive sampling. Qualitative data of stroke with and without seizure are gathered from medical record. Excel 2010 and SPSS24 used for tabulation and data analysis, respectively. Result From 190 samples, post-stroke seizure has insignificant distribution among stroke subtype groups, specifically 48.7% hemorrhagic and 45.7% ischemic (p-value = 0.875; odds ratio [OR] 1.129; 95% confidence interval [CI95] 0.558 – 2.284). 51.4% of sample is comprised by male and 39.2% by female, although gender was not significantly associated with post-stroke seizure (p-value = 0.133; odds ratio [OR] 1.634; 95% confidence interval [CI95] 0.910 – 2.934). Likewise, age of ≥ 65 years (48.1%) and < 65 (45.7%) has no meaningful relation to post-stroke seizure (p-value = 0.892; odds ratio [OR] 1.102; 95% confidence interval [CI95] 0.582 – 2.088). Conclusion Stroke subtype do not significantly affect incidence of post-stroke seizure. Gender and age also are insignificant factors toward post-stroke seizure incidence / Latar Belakang Stroke adalah penyakit serebrovaskuler yang mengkontribusikan 113,000,000 kasus disabilitas dan 6,500,000 kematian di dunia. Di Indonesia, stroke dengan prevalensi 12.1% menyebabkan mortalitas sebesar 15.4%. 12% pasien stroke mengalami kejang. 80% penderita kejang berasal dari negara berkembang, termasuk Indonesia. Penelitian menunjukkan bahwa prognosis kejang pasca stroke lebih buruk dibandingkan stroke tanpa kejang. Berbagai penelitan menunjukkan kejang pasca stroke lebih tinggi pada stroke hemoragik (4.3 – 24%) dibandingkan iskemik (2 – 13.5%). Tujuan Penelitian ini bertujuan untuk mengetahui hubungan subtipe stroke terhadap kejadian kejang. Metode Penelitian Penelitian cross-sectional ini dilakukan di Rekam Medis Rumah Sakit Siloam, Karawaci pada Februari sampai April 2018. Sampling purposif digunakan untuk pengambilan 190 sampel. Data kualitatif stroke dengan dan tanpa kejang diambil dari rekam medis. Microsoft Excel 2010 digunakan untuk tabulasi, sedangkan SPSS24 untuk analisis data. Hasil Dari 190 sampel, kejang pasca stroke diantara kelompok subtipe stroke tidak berbeda secara proporsional, yakni 48.7% hemoragik dan 45.7% iskemik (p-value = 0.875; odds ratio [OR] 1.129; 95% confidence interval [CI95] 0.558 – 2.284). Hubungan jenis kelamin dengan kejang pasca stroke tidak signifikan, dimana laki – laki mencakup 51.4% dan perempuan 39.2% (p-value = 0.133; odds ratio [OR] 1.634; 95% confidence interval [CI95] 0.910 – 2.934). Usia ≥ 65 tahun (48.1%) dan < 65 (45.7%) tidak memiliki hubungan bermakna terhadap kejang pasca stroke (p-value = 0.892; odds ratio [OR] 1.102; 95% confidence interval [CI95] 0.582 – 2.088). Kesimpulan Subtipe stroke tidak memiliki hubungan signifikan terhadap kejadian kejang pasca stroke. Jenis kelamin dan usia juga tidak memiliki hubungan signifikan dengan kejadian kejang pasca stroke.

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