This research aims to determine the effect of e-service quality on Uniqlo Online Store e-loyalty which is mediated by overall e-service quality and e-satisfaction. Large companies are currently using technology to be able to market their products more widely, one of them is a fashion retailer company, namely Uniqlo, which uses websites and applications as online stores to be able to market their products where eservice quality is very influential here so that consumer e-loyalty to the online store is maintained. Based on the results of the research that has been made, it shows that the company needs to improve the e-service quality of the online store so that customers remain loyal. Companies are expected to pay attention to or see consumer e-loyalty from several variables, namely e-service quality, overall e-service quality, and esatisfaction. The author took respondents who had shopped at least 3 times at UNIQLO Online Store in Indonesia. Respondents in this research were 250 respondents. This research use Partial Least Square - Structural Equation Modeling (PLS-SEM) as data analysis method and processed by using SmartPLS software. The results showed that the e-service quality variable has a positive and significant effect on the responses from UNIQLO Online Store customers, so that customers will maintain their e-loyalty which is mediated by overall e-service quality and e-satisfaction.