Kencana, Adrian Hartanto (2015) Aplikasi minuman fermentasi kulit melinjo sebagai anti asam urat pada tikus wistar = Application of melinjo peel based fermented beverage as anti-gout on wistar rats. Bachelor thesis, Universitas Pelita Harapan.
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Abstract
Melinjo peel contains bioactive compounds, namely phenolic and flavonoid
compounds, which can reduce uric acid levels in the bloodstream and urine. The
objective of this research was to determine the effect of melinjo peel based
fermented beverage toward the uric acid levels in the bloodstream and urine of
wistar rats. The fermented beverage was prepared with cultures of Streptococcus
thermophilus, Lactobacillus plantarum, and Lactobacilus fermentum with ratio of
2:1:1, 4% (v/v). The fermented beverage was made with different concentrations
of melinjo peel (2, 4, 6, 8, 10, 15%), sugar (5, 6, 7, and 8%), and skim milk (4, 5,
6, and 7%). The products were fermented for 12 hours and were analyzed for pH,
total titratable acidity, and total lactic acid bacteria. The result showed that based
on these parameters, the best formulations were 2 and 4% melinjo peel, 5%
sugar, and 4% skim milk. The products were then given to wistar rats to
determine the effect of the fermented beverage to the uric acid levels in the
bloodstream and urine. The result showed that the chosen formulations were able
to decrease uric acid levels in the bloodstream and urine of the wistar rats in
contrast with the control. The 2% melinjo peel treatment was able to reduce the
uric acid level as much as 24.70±1.40% in the bloodstream and 30.45±0.97% in
the urine, whereas the 4% melinjo peel treatment was able to reduce the uric acid
level as much as 36.76±1.22% in the bloodstream and 53.77±0.76% in the urine.
On the other hand, allopurinol was shown to reduce the uric acid level as much as
48.78±2.20% in the bloodstream and 56.32±1.29% in the urine. In conclusion,
melinjo peel based fermented beverage is able to reduce uric acid levels in the
bloodstream and urine of wistar rats although not as effective as allopurinol.
Item Type: | Thesis (Bachelor) |
---|---|
Creators: | Creators NIM Email ORCID Kencana, Adrian Hartanto NIM03420110039 AHKENCANA@GMAIL.COM UNSPECIFIED |
Contributors: | Contribution Contributors NIDN/NIDK Email Thesis advisor Parhusip, Adolf Jan Nexson NIDN0107016701 UNSPECIFIED Thesis advisor Eveline, Eveline NIDN0308048201 UNSPECIFIED |
Additional Information: | SK 34-11 KEN a |
Uncontrolled Keywords: | melinjo peel ; fermented beverage ; uric acid ; wistar rats ; allopurinol |
Subjects: | T Technology > TP Chemical technology > TP368-456 Food processing and manufacture |
Divisions: | University Subject > Current > Faculty/School - UPH Karawaci > Faculty of Science and Technology > Food Technology Current > Faculty/School - UPH Karawaci > Faculty of Science and Technology > Food Technology |
Depositing User: | Users 17 not found. |
Date Deposited: | 16 Oct 2018 08:04 |
Last Modified: | 20 Sep 2021 03:12 |
URI: | http://repository.uph.edu/id/eprint/1838 |