In this age of globalization, the business world has become more competitive causing the survival and sustained growth of a company lies in its ability to attract investor to invest in their companies. The company is said to be superior if the company is able to give high stock returns because stock returns are one of profits type that expected by investors. The concepts used in measuring returns can be varied. In this study variables used to measure stock returns is EVA, OCF, RI, EPS and DOL. This research was aimed to analyze the effect of EVA, OCF, RI, EPS and DOL on stock returns of pharmaceutical companies listed in Indonesian stock exchange period 2012-2016. This research used a quantitative approach and secondary data sources. As for data collection method used is the documentation technique. And analysis tool used is multiple linear regression which is using partial test or T-test and simultaneous test or F test. The population of this research is the Pharmaceutical companies which are listed in Indonesia Stock Exchange period 2012-2016 by 10 companies. This research uses purposive sampling technique to get the desired sample. The result showed that EVA and OCF partially have negative and insignificant effect toward stock return. EPS and DOL partially showed a positive and insignificant effect on stock return. However, RI partially showed a negative and significant effect on stock return. Moreover, simultaneously all independent variables had a significant effect on stock returns.