Background: In developing countries Acute Respiratory Infection (ARI) is one of the diseases that cause death in toddlers. Smoking behavior is one of the factors that cause ARI, especially in passive smokers. ARI is the most common pattern of disease in Public Health Centre (Puskesmas) Puuweri as much as 44.1%. Objective: To determine the relationship of smoking behavior of family members with ARI events in toddlers in Integrated Healthcare Post (posyandu) fostered by Public Health Center (puskesmas) Puuweri. Method: This study uses a correlational quantitative method with a cross-sectional approach. The population that will be used in this study are mothers with children under five who come to the posyandu and 32 samples are taken. The sampling technique used in this study is accidental sampling technique. Results: Statistical test results found that smoking behavior of family members in the home there were 16 respondents (50%) while there were 8 ARI incidents (25%) that occurred from 32 respondents. Based on the results of the bivariate analysis test it was found that there was no relationship between smoking behavior of family members with the incidence of acute respiratory infections in toddlers in the health center assisted by Puuweri Puskesmas with p-value 0.414 > α (0.05) and OR value = 1.975. Recommendation: We expected that the puskesmas can maintain and improve health socialization to mothers with children under five about risk factors for ARI in infants and for further researchers to be able to examine other ARI risk factors such as exclusive breastfeeding, malnutrition, air pollution, etc.