Latar belakang : Covid-19 adalah penyakit yang sudah menyebar keseluruh dunia dan menyebabkan angka mortalitas yang tinggi dengan angka penularan sebanyak 425.493 kasus termasuk di Indonesia. Kasus Covid-19 yang terjadi di Indonesia, salah satunya di Kabupaten Serang yang mimiliki pariwisata yang tinggi dan menyebabkan Kabupaten Serang menjadi salah satu zona merah daerah Covid-19. Peningkatan ini kemungkinan terjadi karena perilaku masyarakat terhadap epidemi Covid-19 yang dipengaruhi oleh pengetahuan dan kesadaran masyarakat itu sendiri. Tujuan penelitian: Mengidentifikasi “Gambaran Pengetahuan Masyarakat Terhadap Covid-19 di Kabupaten Serang” Metode Penelitian: Penelitian ini menggunakan metode deskriptif kuantitatif. Teknik sampling yang digunakan adalah teknik purposive sampling. Sampel pada penelitian ini berjumlah 400 orang masyarakat Kabupaten Serang. Instrumen yang digunakan adalah kuesioner pengetahuan. Teknik analisa data yang digunakan adalah analisa univariat. Penelitian ini dilakukan pada bulan Januari- April 2020. Hasil: sebanyak 389 responden memiliki pengetahuan yang tinggi dengan persentase 97% dan 11 orang responden memiliki pengetahuan yang rendah dengan persentase 3%. Rekomendasi: Bagi peneliti selanjutnya, disarankan faktor-faktor yang memengaruhi perilaku masyarakat dalam pencegahan dan pengendalian virus Covid-19/Background: Covid-19 is a disease that has spread throughout the world and causes a high mortality rate with as many transmission rates.425,493 cases including in Indonesia. The Covid-19 case that occurred in Indonesia, one of which is in Serang Regency which has high tourism and has caused Serang Regency to become one of the red zones in the Covid-19 area. This increase is likely occurring due to people's behavior towards the Covid-19 epidemic which was influenced by the knowledge and awareness of the community itself. The research objective: To identify the the Public Knowledge regarding the fight Against Covid-19 in Serang Regency". Research Methods: This study used a quantitative descriptive method. The sampling technique used was purposive sampling technique. The sample in this study amounted to 400 people from Serang Regency. The instrument used was a knowledge questionnaire. The data analysis technique used is univariate analysis. This research was conducted in January-April 2020. Results: as many as 389 respondents had high knowledge with a percentage of 97% and 11 respondents had low knowledge with a percentage of 3%. Recommendation: For future researchers, it is suggested to be able to further examine the factors that influence people's behavior in preventing and controlling the Covid-19 virus.