Disturbance in communication known as interference, happens because of the usage of the same frequency or adjacent frequencies. The frequency spectrum allocation 4G LTE FDD occupies an adjacent uplink and downlink frequency, thus potentially cause interferences. The amount of interference depends on the power of the interferer. The higher the number of interferers may cause higher outage probability. Therefore, it is important to analyze the impact of increasing the number of interferers to the percentage of outage probability. Three interference scenarios are used in this research. The first scenario is when “Base Station interfere Mobile Station,” the second scenario is when “Mobile Station interfere Base Station,” and the third scenario is when “Mobile Station interfere another Mobile Station.” Propagation model COST-231 and Walfish-Ikegami are used to do the research. The method of determining the outage probability refers to the Signal to Interference Ratio (SIR) and sensitivity. In this research the simulation is done using MATLAB. The result of this research shows that when the number of interferer increases, the interference also increases. The result shows that the largest impact of interference occurs in the “Base Station interfere Mobile Station” scenario when there are five Base Stations interfere a Mobile Station with the distance of transmitter to the receiver within 3 km, the Minimum Distance Separation (MSD) of 1 km, a standard deviation of 8 dB, and the outage probability is 52,81%. Meanwhile, using the power control techniques in the “Base Station interfere Mobile Station” scenario, the outage percentage is under 5%, the worst result is 3,37% when there are three interferers at a distance of 1,5 km, Minimum Distance Separation (MSD) of 1 km, and a standard deviation of 10 dB. / Gangguan dalam komunikasi yang lebih dikenal dengan interferensi, dapat terjadi karena pemakaian frekuensi yang sama atau berdekatan. Dalam alokasi spektrum frekuensi 4G LTE FDD antar Operator 4G LTE di Indonesia terdapat frekuensi uplink dan downlink yang bersebelahan, sehingga berpotensi menimbulkan interferensi. Besar interferensi tergantung pada daya penginterferensi. Semakin banyak penginterferensi, maka semakin meningkat kegagalan dalam komunikasi. Oleh karena itu, perlu dilihat seberapa besar persentase outage probabilitiy seiring dengan penambahan jumlah penginterferensi. Dalam penelitian ini dianalisis tiga skenario interferensi, yaitu Base Station menginterferensi Mobile Station, Mobile Station menginterferensi Base Station, dan Mobile Station menginterferensi Mobile Station. Model propagasi dalam penelitian ini adalah COST-231 dan Walfish-Ikegami. Metode penelitian dalam menentukan outage probability mengacu pada Signal to Interference Ratio (SIR) dan kepekaan (sensitivity). Penelitian ini dilakukan dengan simulasi menggunakan software MATLAB. Hasil penelitian, menunjukkan bahwa ketika jumlah penginterferensi meningkat, interferensi yang terjadi semakin tinggi. Hasil simulasi menunjukkan bahwa dampak interferensi terbesar terjadi pada skenario Base Station menginterferensi Mobile Station saat ada lima Base Station menginterferensi Mobile Station dengan jarak transmitter ke receiver 3 km, Minimum Separation Distance (MSD) 1 km, standar deviasi 8 dB dengan persentase 52,81%. Sementara itu dengan teknik power control yang disimulasikan pada skenario Mobile Station menginterferensi Base Station, hasil persentase outage probability tidak pernah di atas 5%, hasil terburuk adalah 3,37% saat ada tiga penginterferensi pada jarak transmitter ke receiver 1,5 km, Minimum Separation Distance (MSD) 1 km, dan standar deviasi 10 dB.