Background: Professional Quality of Life (ProQOL) is a quality felt by someone in helping others who experienced suffering and trauma. Professional Quality of Life (ProQOL) consists of positive aspects or compassion satisfaction and negative aspects or compassion fatigue which are divided into burnout and secondary traumatic stress. Preliminary data showed that seven out of ten nurses feels tired for being a nurse because of of their tasks, their patients or their coworkers. On the other hand, three nurses feel happy for beinga nurse as they can help others and became God’s representative for showing love. Purpose: The purpose of this research is to describe the Professional Quality of Life of oncology nurses in one private Hospital in west Indonesia. Methode: This research is a descriptive research with a quantitative approach. This research will use Professional Quality of Life (ProQOL) scale questionnaire which developed by Stamm (2010) and has been translated into Bahasa Indonesia. The questions in this questionnaire consist of 30 questions that represent the positive and negative aspects of ProQOL. Findings: Nineteen nurses (44,2%) experienced a moderate compassion satisfaction. Additionally, 41 nurses (95,3%) experienced a moderate burnout and 26 nurses (60,5%) experienced low secondary traumatic stress. Suggestion: Future researchers may research the factors behind compassion fatigue, burnout, and secondary traumatic stress on oncology nurses in a complex manner.