Innovation Outputs merupakan hal penting dalam meningkatkan kualitas layanan kesehatan didalam situasi global yang terus berubah terutama dalam pandemi COVID-19. Penelitian ini merupakan penelitian kuantitatif dengan pendekatan cross sectional. Metode pengambilan sampel yang digunakan adalah non-probability sampling, dengan instrumen kuisioner berisi 60 item pertanyaan yang berkaitan dengan variabel yang diteliti pada bulan September-November 2022 di RS XYZ. Total responden adalah 170 perawat. Analisis statistik yang digunakan adalah Structural Equation Modelling dengan menggunakan software SmartPLS. Kesimpulan dari penelitian ini adalah Work Engagement (t-statistic=3.143, p-value=0.001), Perceived Organizational Support (t-statistic=6.371, p-value=0.000) dan Self Efficacy (t-statistic=4.036, p-value=0.000), mempunyai pengaruh positif dan signifikan terhadap Innovative Behaviour serta Innovative Behaviour (t-statistic=9.182, p-value=0.000), mempunyai pengaruh positif dan signifikan terhadap Innovative Outputs. Sedangkan Occupational Stress (t-statistic=0.219, p-value=0.413), dan Anxiety (t-statistic=3.402, p-value=0.344), tidak mempunyai pengaruh yang signifikan terhadap Innovative Behaviour. / Innovation Outputs are important in improving the quality of health services in a changing global situation, especially in the COVID-19 pandemic. This research is a quantitative study with a cross sectional approach. Researcher used non-probability sampling method, and a questionnaire containing 60 question items related to the variables studied in September-November 2022 at XYZ Hospital. The total respondents were 170 nurses. Structural Equation Modelling using SmartPLS software is used for statistical analysis. The conclusion of this study is that Work Engagement (t-statistic=3.143, p-value=0.001), Perceived Organizational Support (t-statistic=6.371, p-value=0.000) and Self Efficacy (t-statistic=4.036, p-value=0.000), have a positive and significant influence on Innovative Behaviour and Innovative Behaviour (t-statistic=9.182, p-value=0.000), has a positive and significant influence on Innovative Outputs. Whereas Occupational Stress (t-statistic=0.219, p-value=0.413), and Anxiety (t-statistic=3.402, p-value=0.344), do not have a significant influence on Innovative Behaviour.