Instalasi Gawat Darurat (IGD) merupakan unit yang kompleks dengan lingkungan yang dinamis yaitu cepat berubah, ketidakpastian yang tinggi, dan banyak kemungkinan tidak terduga bisa terjadi pada unit ini. Untuk itu, rumah sakit perlu menerapkan leadership dan HR practices yang tepat agar organizational agility dan kinerja karyawan di IGD dapat ditingkatkan. Penelitian ini bertujuan untuk menganalisis pengaruh Leadership dan HR Practices terhadap Organizational Agility dan Emplovee Performance pada unit IGD Rumah Sakit XYZ, Bekasi Pengambilan sampel menggunakan teknik sensus dengan jumlah sampel sebanyak 65 orang tenaga kesehatan di IGD. Teknik analisis data yang digunakan pada penelitian in adalah Partial Least Square - Structural Equation Modeling (PLS- SEM) dengan softiware SmartPLS. Hasil penelitian menunjukkan Leadership berpengaruh positif signifikan terhadap HR Practices, namun tidak bepengaruh terhadap Organizational Agility dan Employee Performance. HR Practices berpengaruh positif signifikan terhadap Organizational Agility dan Employee Performance. Selanjutnya, Organizational Agility berpengaruh positif signifikan terhadap Employee Performance. Meningkatnya implementasi praktik HR dan organizational agility akan mampu meningkatkan employee performance. Manajemen RS XYZ. disarankan untuk berperan aktif dalam melakukan monitoring dan evaluasi terhadap karyawan serta lebih miningkatkan respon dan adaptasi dalam melakukan penanganan di IGD. / The Emergency Room (ER) is a complex unit with dynamic environment that is fast changing, high uncertainty, and many unexpected possibilities can occur in this unit. Therefore, hospitals need to implement appropriate leadership and HR practices so that organizational agility and employee performance in the ER can be improved. This study aim to analyze the effect of Leadership andH R Practices on Organizational Agility and Employee Performance in the ER of XYZ Hospital in Bekasi. Census sampling was used in this study with a total of 65 medical and health personnels. This study used Partial Least Square - Structural Equation Modeling (PLS-SEM) to analyze the data with SmartPIS software. Results showed LeadershiphadapositivesignificanteffectonHRPractices, buthadnosignificant effect on Organizational Agility and Employee Performance. HR Practices had a positive significant effect on Organizational Agility and Employee Performance. Organizational Agility also had a positive significant effect on Employee Performance. Enhancing the implementation of HR practices and organizational agility can improve employee performance. The management ofXYZHospital may consider to play an active role in monitoring and evaluating their employees, as well as improving responses and adaptation in carrying out responsibilities in the ER.