Penelitian ini bertujuan untuk menilai hubungan professional commitment, job satisfaction, transformational leadership style, meaningful recognition, insentif finansial, working environment, dan patient safety culture. Model penelitian yang digunakan dalam penelitian ini merupakan modifikasi dari penelitian penelitian terdahulu yang kemudian diuji pada populasi perawat di rumah sakit X di Provinsi Kepulauan Riau. Pengambilan data dilakukan secara total sampling dengan responden sebanyak 243 responden. Penelitian ini menggunakan metode analisa PLS-SEM. Hasil yang didapatkan adalah insentif finansial, dan meaningful recognition memiliki pengaruh negatif yang signifikan terhadap patient safety culture, professional commitment, job satisfaction, transformational leadership style, working environment memiliki pengaruh positif yang signifikan terhadap patient safety culture. Sebaliknya, meaningful recognition memberikan pengaruh positif terhadap patient safety culture apabila dimediasi oleh professional commitment. Hal ini juga ditemukan pada hubungan, finansial insentif yang berpengaruh positif apabila dimediasi oleh job satisfaction terhadap patient safety culture. Professional commitment merupakan variabel yang paling berpengaruh terhadap patient safety culture. / This research aims to assess the relationship between professional commitment, job satisfaction, transformational leadership style, meaningful recognition, financial incentives, working environment, and patient safety culture. The research model used in this research is a modification of previous research which was then tested on a population of nurses at Hospital X in the Kepulauan Riau Province. Data collection was carried out using total sampling with a total of 243 respondents. This research uses the PLS-SEM analysis method. The results obtained are that financial incentives, and meaningful recognition have a significant negative influence on patient safety culture, professional commitment, job satisfaction, transformational style, working environment have a significant positive influence on patient safety culture. On the other hand, meaningful recognition has a positive influence on patient safety culture if it is mediated by professional commitment. This was also found in the relationship, financial incentives which had a positive effect if mediated by job satisfaction on patient safety culture. Professional commitment is the variable that has the most influence on patient safety culture.