Hubungan antara subtipe molekuler karsinoma payudara invasif terhadap usia saat diagnosis di rumah sakit siloam karawaci tahun 2016 – 2017 = Relationship between molecular subtipe of invasive breast carsinoma toward the age of diagnosis at siloam karawaci hospital in 2016 – 2017

Angelica, Vena (2018) Hubungan antara subtipe molekuler karsinoma payudara invasif terhadap usia saat diagnosis di rumah sakit siloam karawaci tahun 2016 – 2017 = Relationship between molecular subtipe of invasive breast carsinoma toward the age of diagnosis at siloam karawaci hospital in 2016 – 2017. Bachelor thesis, Universitas Pelita Harapan.

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Abstract

Breast cancer is the number one threat to women worldwide. In Indonesia, breast cancer is the second most common cancer in women, after cervical cancer. Several studies have shown that age is not only a risk factor for breast cancer but also has an association on molecular subtype invasive breast carcinoma. However, the results of the research are inconsistent in different races and ethnic groups, so further research is needed. This study aims to determine the relationship of molecular subtype invasive breast carcinoma to patient age at diagnosis. This research is an analytical research with cross-sectional design study that conducted in Rumah Sakit Siloam Karawaci in January – May 2018. The samples of this research is 50 people. Results of this research will processed using software SPSS 23.0 and statistically tested using Chi Square method. The results obtained were Luminal A and Luminal B (ER/PR positive) was found to be dominant at all ages (p-value = 0.332), most of them are Luminal B (84%). So, it can be concluded that there is no significant relationship between molecular subtype of invasive breast carcinoma and age at diagnosis / Kanker payudara merupakan ancaman nomor satu wanita di seluruh dunia. Di Indonesia, kanker payudara menempati posisi kedua kanker yang paling sering pada wanita, setelah kanker serviks. Beberapa penelitian membuktikan bahwa usia tidak hanya menjadi faktor resiko terhadap peningkatan kanker payudara tetapi juga memiliki hubungan terhadap subtipe molekuler karsinoma payudara invasif. Namun, hasil penelitian yang didapatkan bersifat tidak konsisten pada ras dan etnis yang berbeda sehingga perlu diadakan penelitian lebih lanjut. Penelitian ini bertujuan untuk mengetahui hubungan subtipe molekuler karsinoma payudara invasif terhadap usia pasien saat diagnosis. Penelitian ini merupakan penelitian analitik dengan studi potong lintang yang dilaksanakan di Rumah Sakit Siloam Karawaci pada periode Januari – Mei 2018. Sampel yang akan diambil adalah pasien yang memenuhi kriteria sebanyak 50 orang. Hasil penelitian yang didapatkan akan diolah menggunakan software SPSS 23.0 dan diuji statistik menggunakan metode Chi Square. Hasil penelitian yang didapatkan yaitu Luminal A dan Luminal B (ER/PR positif) dominan pada segala usia (p-value = 0.332), subtipe paling banyak adalah Luminal B (84%). Jadi, dapat disimpulkan bahwa tidak ada hubungan yang signifikan antara subtipe molekuler karsinoma payudara invasif terhadap usia saat diagnosis.

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