Pola kepekaan acinetobacter baumannii terhadap berbagai macam antibiotik pada pasien ICU Rumah Sakit Pendidikan Siloam = Sensitivity pattern of acinetobacter baumannii towards many types of antibiotics in Siloam Teaching Hospital ICU patients

Juandi, Jane (2018) Pola kepekaan acinetobacter baumannii terhadap berbagai macam antibiotik pada pasien ICU Rumah Sakit Pendidikan Siloam = Sensitivity pattern of acinetobacter baumannii towards many types of antibiotics in Siloam Teaching Hospital ICU patients. Bachelor thesis, Universitas Pelita Harapan.

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Abstract

Background Acinetobacter baumannii is one of the common bacteria found in Intensive Care Unit (ICU) patients. As well as, it is a bacillus gram negative bacteria which is opportunistic, pathogenic, virulent, has broad spectrum, and a high prevalence of Multi Drug Resistance (MDR) in the ICU. Objective To obtain sensitivity pattern of Acinetobacter baumannii towards many types of antibiotics in ICU. Materials and Methods This is a retrospective cross-sectional observational study in 221 patients admitted to Siloam Teaching Hospital ICU from January 2016 to December 2017. Data will be obtained from Siloam Teaching Hospital ICU patient’s database. Data tabulation and analysis will be done using Microsoft Excel 2010 and SPSS 24. Results From the total of 221 samples in this study, 67.9% of them are men infected or colonized by A.baumannii with an average age of 51.25 years. The highest source of specimens in this study came from sputum with 83.7%. The susceptibility pattern of A.baumannii to various antibiotics was found, whereas the antibiotics which are still sensitive are: Amikacin with 59.7%, Cefoperazone/Sulbactam with 58.8%, Tigecycline with 46.2%, and Trimethoprim/Sulfamethoxazole with 39.8 %. Conclusion From this study, we developed a sensitivity pattern of Acinetobacter baumannii to various antibiotics at Siloam Teaching Hospital ICU, which are still sensitive for A.baumannii infected or colonized patients are: Amikacin, Cefoperazone/Sulbactam, Tigecycline, and Trimethoprim/Sulfamethoxazole / Latar Belakang Acinetobacter baumannii merupakan salah satu bakteri yang sering ditemukan pada pasien-pasien Intensive Care Unit (ICU). Serta, merupakan bakteri gram negatif basil yang bersifat oportunistik, patogenik, virulen, memiliki spektrum luas, serta memiliki prevalensi Multi Drug Resistance (MDR) yang tinggi di ICU. Objektif Mengetahui pola kepekaan Acinetobacter baumannii terhadap berbagai macam antibiotik di ICU. Materi & Metodologi Penelitian ini menggunakan studi observasional retrospektif cross sectional pada 221 pasien ICU Rumah Sakit Pendidikan Siloam yang dirawat dari Januari 2016 sampai Desember 2017. Data penelitian didapat dari database pasien ICU Rumah Sakit Pendidikan Siloam. Tabulasi dan analisis data menggunakan program Microsoft Excel 2010 dan SPSS 24. Hasil Dari total 221 sampel penelitian, sebanyak 67,9 % berjenis kelamin pria terinfeksi atau terkolonisasi A.baumannii dengan rata-rata usia 51,25 tahun. Sumber spesimen paling banyak pada penelitian ini berasal dari sputum dengan 83,7 %. Pola kepekaan A.baumannii terhadap berbagai macam antibiotik ditemukan, di mana antibiotik yang masih senstif yaitu: Amikacin dengan 59,7 %, Cefoperazone/Sulbactam dengan 58,8%, Tigecycline dengan 46,2 %, dan Trimethoprim/Sulfamethoxazole dengan 39,8%. Kesimpulan Dari penelitian ini, maka diperoleh pola kepekaan Acinetobacter baumannii terhadap berbagai macam antibiotik di ICU Rumah Sakit Pendidikan Siloam, di mana antibiotik yang masih sensitif untuk pasien yang terinfeksi atau terkolonisasi oleh A.baumannii yaitu: Amikacin, Cefoperazone/Sulbactam, Tigecycline, dan Trimethoprim/Sulfamethoxazole.

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