Monalisa, Anita (2024) Penetapan profil disolusi sediaan sprinkle formulation dari ekstrak buah mengkudu (morinda citrifolia L.). Bachelor thesis, Universitas Pelita Harapan.
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Abstract
Buah mengkudu (Morinda citrifolia L.) memiliki kemampuan sebagai
imunomodulator karena adanya senyawa scopolamine dan kuersetin. Aktivitas
imunomodulator dari buah mengkudu ini diaplikasikan pada sediaan farmasi
dengan diformulasikan menjadi sediaan granul halus (sprinkle formulation) bagi
bagi anak-anak dalam meningkatkan sistem imun. Pada penelitian ini akan
dilakukan pengujian disolusi terhadap sediaan sprinkle formulatioin menggunakan
alat tipe 2 (dayung) dan menggunakan medium dengan nilai pH 1,2 sesuai kondisi
lambung saat berpuasa (preprandial) dan pH 4,5 terisi makanan (postprandial).
Sampel yang diambil selama uji disolusi ditetapkan kadarnya menggunakan
spektrofotometri UV-Vis pada panjang gelombang maksimum. Hasil yang
diperoleh profil disolusi senyawa kuersetin dalam sprinkle formulation ekstrak
buah mengkudu (Morinda citrifolia. L) pada menit ke-60 dalam medium pH 1,2
adalah 57,5039%±1,3316 dan pH 4,5 adalah 86,2392%±0,6895. Kemudian hasil uji
statistik Mann-Whitney Test kadar total Flavonoid (mgQE/gram) pada ekstrak,
sprinkle formulation, jumlah terdisolusi obat pada menit ke-60 dalam medium pH
1,2 dan pH 4,5 memberikan hasil p value ≥ 0,05 yang berarti tidak ada perbedaan
bermakna dari kadar total Flavonoid pada setiap sampel. / Noni fruit (Morinda citrifolia L.) has the ability as an immunomodulator due to the
presence of scopolamine and quercetin compounds. The immunomodulatory
activity of noni fruit is applied to pharmaceutical preparations by formulating it
into a fine granule preparation(sprinkle formulation) for children in improving the
immune system. In this study, dissolution testing of sprinkle formulations will be
carried out using a type 2 device (paddle) and using a medium with a pH value of
1.2 according to stomach conditions when fasting (preprandial) and pH 4.5 filled
with food(postprandial). Samples taken during the dissolution test were determined
using UV-Vis spectrophotometry at the maximum wavelength. The results obtained
the dissolution profile of quercetin compounds in the sprinkle formulation of noni
fruit extract(Morinda citrifolia. L) at the 60th minute in pH 1.2 medium was
57,5039%±1,3316 and pH 4.5 was 86,2392%±0,6895. Then the results of the
Mann-Whitney Test statistical test of total Flavonoid levels (mgQE/gram) in
extracts, sprinkle formulations, the amount of drug dissolved at the 60th minute in
pH 1.2 and pH 4.5 medium gave p value ≥ 0.05 which means there is no significant
difference in total Flavonoid levels in each sample.
Item Type: | Thesis (Bachelor) |
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Creators: | Creators NIM Email ORCID Monalisa, Anita NIM01038200032 anitamonalisa2210@gmail.com UNSPECIFIED |
Contributors: | Contribution Contributors NIDN/NIDK Email Thesis advisor Ayuningtyas, Nurista NIDN0630118904 nurista.ayuningtyas@uph.edu Thesis advisor Sugiarto, Yohana NIDN8913000020 yohana.sugiarto@lecturer.uph.edu |
Uncontrolled Keywords: | buah mengkudu; granul; disolusi; formulasi; imunomodulator |
Subjects: | R Medicine > RS Pharmacy and materia medica |
Divisions: | University Subject > Current > Faculty/School - UPH Karawaci > Faculty of Health Sciences > Pharmacy Current > Faculty/School - UPH Karawaci > Faculty of Health Sciences > Pharmacy |
Depositing User: | ANITA MONALISA |
Date Deposited: | 18 Jun 2024 09:30 |
Last Modified: | 18 Jun 2024 09:30 |
URI: | http://repository.uph.edu/id/eprint/63463 |