Formulasi sediaan transdermal patch ekstrak lempuyang (zingiber zerumbet L.) sebagai antivarises

Sugiharto, Romario (2024) Formulasi sediaan transdermal patch ekstrak lempuyang (zingiber zerumbet L.) sebagai antivarises. Bachelor thesis, Universitas Pelita Harapan.

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Abstract

Ekstrak lempuyang (Zingiber zerumbet L.) memiliki banyak kandungan, salah satunya adalah zat zerumbone yang dimana memiliki efek farmakologis sebagai anti varises. Varises terjadi akibat pelebaran pembuluh darah dan banyak sekali menyerang pada bagian tungkai kaki. Terdapat sistem penghantaran obat yang dapat memberikan efek farmakologis terhadap penyakit varises salah satunya adalah transdermal. Transdermal merupakan sistem penghantaran obat melalui kulit. Penelitian ini dilakukan dengan tujuan agar formulasi sediaan yang dikembangkan memiliki efek dan bentuk sediaan yang maksimal dan memenuhi persyaratan evaluasi suatu sediaan. Pengujian zat aktif dilakukan dengan uji in vitro dengan uji difusi franz dan spektrofotometri UV-Vis. Hasil yang diperoleh menunjukkan bahwa formula 4 memiliki hasil yang lebih baik dibanding formula lain / Lempuyang extract (Zingiber zerumbet L.) has many ingredients, one of which is the substance zerumbone which has a pharmacological effect as an antivarises. Varicose veins occur due to dilation of blood vessels and many attack the legs. There are drug delivery systems that can provide pharmacological effects against varicose veins, one of which is transdermal. Transdermal is a drug delivery system through the skin. This study was conducted with the aim that the dosage formulation developed has the maximum effect and dosage form and meets the evaluation requirements of a preparation. Testing of active substances was carried out by in vitro testing with franz diffusion test and spectrofotometry UV-Vis. The results obtained show that formula 4 has better results than other formulas.

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