The aim of this study is to examine and analyze the antecedents of patient satisfaction post cardiac catheterization and its impact on health-related quality of life with moderation by perceived severity of cardiac disease. Empirical data analysis collected through purposive sampling. In total of 154 respondents whom answering online questionnaires was analyzed using Partial Least-Structural Equation Modeling (PLS-SEM). The research findings indicate that treatment outcome, patient-physician communication, attentive care, organization of care,and hospital servicescape significantly and positively influence patient satisfaction after cardiac catheterization (p-value <0.05; CI 95%). Furthermore, patient satisfaction after cardiac catheterization significantly and positively influences health-related quality of life (p=0,000; =0,848). Perceived severity of cardiac disease does not moderate the relationship between patient satisfaction after cardiac catheterization and health-related quality of life. The research model demonstrates moderate explanatory power (R2), which increases to strong explanatory power in segment analysis (PLS-POS). The model also exhibits large predictive relevance (Q2_predict) for the patient satisfaction after cardiac atheterization variable. Overall predictive ability is confirmed by results from cross-validated prediction ability tests (CVPAT). The findings have managerial implications for developing factors which can improve patient satisfaction post cardiac catheterization in XYZ hospital. / Penelitian ini bertujuan guna menguji dan menganalisis anteseden dari patient satisfaction pasca cardiac catheterization serta dampaknya pada health related quality of life dengan moderasi perceived severity of cardiac disease. Data empiris responden yang merupakan pasien yang telah menjalani kateterisasi jantung dikumpulkan secara purposive sampling. Sejumlah 154 responden dianalisis mempergunakan partial least square-structural equation modeling (PLS-SEM) dari kuesioner yang disebarkan secara daring. Hasil penelitian menunjukkan treatment outcome, patient-physician communication, attentive care, organization of care, dan hospital servicescape memiliki pengaruh positif dan signifikan (pvalue <0,05: CI 95%) terhadap patient satisfaction. Selanjutnya, patient satisfaction berpengaruh signifikan dan positif terhadap health-related quality of life (p=0,000; =0,848). Perceived severity of cardiac disease ditemukan tidak memoderasi secara signifikan terhadap pengaruh patient satisfaction after cardiac catheterization terhadap health-related quality of life. Model penelitian ini memiliki kemampuan explanatory (R2) yang moderat, namun dapat meningkat menjadi strong explanatory power dalam analisis segmen sampel (PLS-POS). Model penelitian ini juga memiliki large predictive relevance (Q2_predict) untuk variabel patient satisfaction after cardiac Catheterization. Kemampuan prediksi secara keseluruhan dikonfirmasi oleh cross validated prediction ability test (CVPAT). Hasil temuan dapat memberikan implikasi manajerial untuk meningkatkan faktor-faktor yang memengaruhi kepuasan pasien yang menjalani kateterisasi jantung di rumah sakit swasta XYZ.