Latar Belakang: Pendidikan kedokteran merupakan salah satu pendidikan yang dianggap berat yang menyebabkan buruknya kualitas tidur mahasiswa. Kualitas tidur terbukti terlibat dalam aspek-aspek psychological well-being sehingga peneliti melaksanakan penelitian ini. / Background: Medical school is considered difficult and causes poor sleep quality for the students. Sleep quality has been proven to be involved in aspects of psychological well-being so researchers carried out this research. Tujuan Penelitian: Mengetahui hubungan antara peningkatan kualitas tidur dengan peningkatan psychological well-being mahasiswa preklinik Fakultas Kedokteran Universitas Pelita Harapan. / Objective: To know the relationship between improvement of sleep quality and improvement of psychological well-being of pre-clinical students at the Faculty of Medicine Universitas Pelita Harapan. Hipotesis: Terdapat hubungan antara peningkatan kualitas tidur dengan peningkatan psychological well-being pada mahasiswa pre-klinik Fakultas Kedokteran Universitas Pelita Harapan. / Hypothesis: There is a relationship between improvement of sleep quality and improvement of psychological well-being in pre-clinical students at the Faculty of Medicine Universitas Pelita Harapan. Metode: Penelitian ini menggunakan desain studi cross-sectional yang dilaksanakan pada 47 responden penelitian mahasiswa pre-klinik Fakultas Kedokteran Universitas Pelita Harapan yang memenuhi kriteria penelitian dengan teknik non-probability sampling. Penelitian ini akan dilakukan dengan menggunakan kuesioner Ryff's Psychological Well-Being (RPSWB) dan Pittsburgh's Sleep Quality Index (PSQI). / Method: This research used a cross-sectional study design which was carried out on 47 research respondents from pre-clinical students at the Faculty of Medicine Universitas Pelita Harapan who met the research criteria using a non-probability sampling technique. This research will be conducted using the Ryff's Psychological Well-Being (RPSWB) and Pittsburgh's Sleep Quality Index (PSQI) questionnaires. Hasil: Hasil uji Chi-Square menunjukan analisis hubungan antara kualitas tidur dengan psychological well-being dengan nilai p-value sebesar 0,0333 dan OR 0,114 (95% CI = 0,014-0,903). / Results: Chi-Square test results show an analysis of the relationship between sleep quality and psychological well-being with a p-value of 0.0333 and OR 0.114 (95% CI = 0.014-0.903). Kesimpulan: terdapat hubungan antara peningkatan kualitas tidur dengan peningkatan psychological well-being pada mahasiswa pre-klinik Fakultas Kedokteran Universitas Pelita Harapan. / Conclusion: There is a relationship between improvement of sleep quality and improvement of psychological well-being in pre-clinical students at the Faculty of Medicine, Pelita Harapan University. Referensi: 112 (1975-2023) Kata kunci: kualitas tidur, psychological well-being, pittburgh's sleep quality index, ryff's psychological well-being, mahasiswa fakultas kedokteran.