Gagal ginjal kronik merupakan masalah dunia kesehatan, perawatan yang paling sering dikerjakan adalah hemodialisis, dan gangguan fungsi kognitif merupakan salah satu komplikasi yang sering ditemukan. Namun, terdapat perbedaan hasil mengenai teori ini, sehingga perlu diteliti lebih lanjut. Tujuan penelitian bertujuan untuk mengetahui hubungan antara lama menjalani hemodialisis pada pasien gagal ginjal kronik dengan fungsi kognitif di SHLV Gedung B. Penelitian ini menggunakan metode analitik observasional, dan desain studi potong lintang. Uji statistik yang digunakkan dalam penelitian ini adalah Fisher-Exact. Dari 31 subjek penelitian, P-value=0,026, menunjukkan terdapat hubungan signifikan antara lama menjalani hemodialisis ≥1 tahun sebagai faktor risiko penurunan fungsi kognitif pada pasien gagal ginjal kronik. Odds Ratio menunjukkan risiko penurunan fungsi kognitif 1,583 kali pada pasien gagal ginjal kronik yang menjalani hemodialisis ≥1 tahun. CI 95% berada di 1,123-2,232 menunjukkan penelitian akurat menggambarkan populasi. Mayoritas sampel menjalani hemodialisis ≥1 tahun, 19 orang (61.35%); Nilai MMSE 24-30, 24 orang (77,4%); Usia lanjut (45-65 tahun), 21 orang (67,7%); Tingkat pendidikan SMA dan Perguruan Tinggi, 24 orang (77,4%); Laki-laki, 18 orang (58,1%). ≥1.2 Kt/V, 31 orang (100%); 21 orang (67,7%) tidak menderita “Diabetes Melitus”; 28 orang (90,3%) menderita “Hipertensi”. Hasil penelitian menunjukkan terdapat hubungan signifikan antara pasien gagal ginjal kronik yang menjalani hemodialisis ≥1 tahun dengan penurunan fungsi kognitif di SHLV Gedung B. / Chronic kidney failure is a world health problem, the most frequently used treatments are hemodialysis, and functional disorders Cognition is one of the complications that is often found. However, there are There are differences in results regarding this theory, so it needs to be investigated further. The aim of the study was to determine the relationship between the length of time undergoing hemodialysis in patients chronic kidney failure with cognitive function in SHLV Building B. This study used observational analytical methods and design cross-sectional study. The statistical test used in this research is Fisher-Exact. Of the 31 research subjects, P-value = 0.026, indicating there is a relationship significant duration of hemodialysis ≥1 year as a risk factor decreased cognitive function in chronic kidney failure patients. Odds Ratio showed a 1.583 times risk of cognitive function decline in kidney failure patients chronic patients undergoing hemodialysis ≥1 year. The 95% CI was 1.123-2.232 shows the research accurately describes the population. The majority of samples underwent hemodialysis ≥1 year, 19 people (61.35%); Mark MMSE 24-30, 24 people (77.4%); Elderly age (45-65 years), 21 people (67.7%); High school and tertiary education level, 24 people (77.4%); Male, 18 people (58.1%). ≥1.2 Kt/V, 31 people (100%); 21 people (67.7%) did not suffer "Diabetes mellitus"; 28 people (90.3%) suffered from "Hypertension". The results of the study showed that there was a significant relationship between patients with chronic kidney failure undergoing hemodialysis ≥1 year with decreased cognitive function in SHLV Building B.