Suryadana, Suryadana (2024) OPTIMASI FORMULASI EMULGEL ANTIBAKTERI EKSTRAK ETANOL 70% BUNGA ROSELLA (Hibiscus sabdariffa L.) TERHADAP BAKTERI Staphylococcus epidermidis. Diploma thesis, Universitas Pelita Harapan.
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Abstract
Bunga rosella (Hibiscus sabdariffa L.) memiliki kandungan senyawa metabolit
sekunder yang dapat dimanfaatkan sebagai antibakteri. Staphylococcus epidermidis
adalah salah satu bakteri penyebab jerawat, senyawa antibakteri ada pada tanaman
ini memiliki potensi untuk dijadikan pengobatan anti jerawat. Penelitian ini
bertujuan mengetahui formulasi emulgel antibakteri ekstrak bunga rosella
memenuhi stabilitas dan persyaratan mutu fisik serta mengetahui sediaan emulgel
ekstrak bunga rosella memiliki aktivitas antibakteri terhadap Staphylococcus
epidermidis. Metode penelitian yang digunakan adalah metode eksperimental
dengan pembuatan emulgel dengan variasi konsentrasi carbopol 940 sebagai
gelling agent. Evaluasi yang dilakukan pada sediaan emulgel meliputi uji
organoleptik, pH, homogenitas, viskositas dan daya sebar, uji stabilitas, uji tipe
emulsi dan uji aktivitas antibakteri sediaan emulgel. Aktivitas antibakteri sediaan
emulgel menghasilkan zona hambat F1 (20,13 mm;intermediate), F2 (20,65
mm;intermediate), dan F3 (20,65 mm;intermediate). Hasil uji organoleptik, pH,
homogenitas, viskositas dan daya sebar, uji stabilitas, uji tipe emulsi menunjukkan
formulasi sediaan F1, F2 dan F3 stabil hingga hari keenam. Kesimpulan dari
penelitian ini adalah formulasi sediaan F2 lebih baik dari F1 dan F3 berdasarkan
kemampuan aktivitas antibakteri, dan lebih stabil pada uji daya sebar dan uji
viskositas. / Rosella flowers (Hibiscus sabdariffa L.) contained secondary metabolite
compounds that could be used as antibacterials. Staphylococcus epidermidis was
one of the bacteria causing acne, and an antibacterial compound present in this
plant had the potential to be used as an anti-acne treatment. The study aimed to
determine whether the formulation of antibacterial emulge extracts of rosella
flowers met stability and physical quality requirements, as well as to find out
whether the preparation of emulges of rosella flower extract had antibacterial
activity against Staphylococcus epidermidis. The research method used was an
experimental method involving the formulation of emulsions with varying
concentrations of carbopol 940 as a gelling agent. Evaluations conducted on the
emulge preparations included organoleptic tests, pH, homogeneity, viscosity and
uniformity, stability tests, emulsion type tests, and antibacterial activity tests of the
emulge preparations. The antibacterial activity of the emulge preparations yielded
inhibition zones of F1 (20.13 mm; intermediate), F2 (20.65 mm; intermediate), and
F3 (20.65 mm; intermediate). Results from organoleptic tests, pH, homogeneity,
viscosity and resistance, stability tests, and emulsion type tests indicated that
formulations F1, F2, and F3 were stable up to the sixth day. The study concluded
that the formulation of F2 was superior to F1 and F3 based on its antibacterial
activity and stability in one-bar strength and viscosity tests.
Item Type: | Thesis (Diploma) |
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Creators: | Creators NIM Email ORCID Suryadana, Suryadana NIM01174210018 suryasuryadana@gmail.com UNSPECIFIED |
Contributors: | Contribution Contributors NIDN/NIDK Email Thesis advisor Trisina, Jessica NIDN0303108505 jessica.trisina@lecturer.uph.edu Thesis advisor Andriyani, Andriyani NIDN0313057508 andriyani.fikes@uph.edu |
Uncontrolled Keywords: | rosella; antibakteri; emulgel |
Subjects: | R Medicine > RS Pharmacy and materia medica |
Divisions: | University Subject > Current > Faculty/School - UPH Karawaci > Faculty of Health Sciences > Pharmacy (Diploma) Current > Faculty/School - UPH Karawaci > Faculty of Health Sciences > Pharmacy (Diploma) |
Depositing User: | Suryadana Suryadana |
Date Deposited: | 26 Sep 2024 08:11 |
Last Modified: | 26 Sep 2024 08:13 |
URI: | http://repository.uph.edu/id/eprint/65368 |