Latar Belakang : Kondisi fisik seseorang yang telah memasuki masa lansia akan mengalami penurunan secara berlipat ganda bersifat patologis. Transformasi fisik terjadi dari awal kehidupan hingga masa lanjut usia pada semua bagian organ dan dalam perubahan sistem kemih. Inkontinensia urin adalah permasalahan yang umum dialami oleh lansia. Terjadinya inkontinensia urin mengakibatkan dampak psikologis, sosial, dan ekonomi yang dapat memengaruhi kualitas hidup lansia. Berdasarkan data World Health Organization ditemukan prevalansi gangguan depresi pada populasi lansia mencapai 61,6%. Tujuan Penelitian : Penelitian ini dilakukan untuk mengetahui hubungan antara inkontinensia urin dengan depresi pada lansia di Siloam Hospital Lippo Village Tangerang. Metode : Penelitian ini menggunakan desain studi cross sectional dengan metode studi analitik komparatif kategorik tidak berpasangan dan besar sampel 48 lansia di Siloam Hospitals Lippo Village Gedung B Kabupaten Tangerang yang dilakukan dengan random sampling. Data penelitian didapatkan dari wawancara menggunakan kuesioner dan data rekam medis pasien yang akan dianalisis menggunakan uji statistik Chi-Square. Hasil Penelitian: Dari penelitian ini, sebanyak 30 lansia (62.5%) mengalami inkontinensia urin dan 15 lansia (31.3%) memiliki depresi. Pada analisis chi-square ditemukan hubungan signifikan antara inkontinensia urin dengan depresi pada lansia di Siloam Hospitals Lippo Village Gedung B Kabupaten Tangerang berupa p value 0,04 (<0,05) (OR=6.118, 95% CI= 1.189-31.467; p-value 0,04). Kesimpulan: Terdapat hubungan signifikan antara inkontinensia urin dengan depresi pada lansia di Siloam Hospitals Lippo Village Gedung B Kabupaten Tangerang. Kata Kunci: Inkontinensia Urin, Depresi, Lansia, Kualitas hidup./ Background: The physical condition of a person who has passed into old age will have exposure to multiple pathological. Physical transformation occurs from early life to old age in all parts of the body's organs and tissues, which can be seen in changes in the urinary system or urination system. Urinary incontinence is a common problem among the elderly. The occurrence of urinary incontinence affects psychological, social and economic further the quality of life. Based on data from the World Health Organization, it was found that the prevalence of depressive disorders in the elderly population reached 61.6%. Aim: Analysing the relationship between urine incontinence and depression in elderly of Siloam Hospitals Lippo Village Building B, Tangerang Tools and Methods: This research used a cross-sectional study design with an unpaired categorical comparative analytical study method and 48 sample elderly people at Siloam Hospitals Lippo Village Building B Tangerang Regency, which was thorough using random sampling. Research data was obtained from interviews using questionnaires and patient medical record data which will be analyzed using the Chi-Square statistical test. Result and Discussion: From this research, 30 elderly (62.5%) had urinary incontinence and 15 elderly (31.3%) had depression. In the chi-square analysis, a significant relationship was found between urinary incontinence and depression in the elderly at Siloam Hospitals Lippo Village Building B, Tangerang Regency in the appearance of a p value of 0.04 (<0,05) (OR=6.118, 95% CI= 1.189-31.467; p-value 0,04). Conclusion: There is a significant relationship urine incontinence and depression in elderly of Siloam Hospitals Lippo Village Building B, Tangerang Keywords: Urine Incontinence, Depression, Elderly, Quality of Life