Dion, Nathanael Orin (2024) Hubungan antara diabetes melitus tipe II dan derajat keparahan osteoartritis lutut pada pasien Siloam Hospitals Lippo Village Paviliun B. Bachelor thesis, Universitas Pelita Harapan.
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Abstract
Diabetes Melitus (DM) merupakan salah satu penyakit kronik yang umum terjadi di masyarakat, yang diderita sekitar 10% populasi di dunia, dan dapat dikarakteristikan dengan peningkatan kadar glukosa dalam darah. Osteoartritis (OA) merupakan penyakit degeneratif yang paling umum terjadi dan ditandai dengan hilangnya tulang rawan, pembentukan osteofit, serta sinovitis. Sendi lutut merupakan salah satu sendi yang paling sering terdampak. Kedua penyakit ini merupakan penyakit kronik dan sistemik dengan inflamasi tingkat rendah, serta mempunyai faktor risiko serupa. Individu dengan DM mempunyai insiden OA yang lebih tinggi dan progresivitas penyakit yang lebih cepat dibandingkan dengan individu tanpa DM. Beberapa studi menunjukkan kondisi hiperglikemia berkontribusi terhadap kerusakan sendi pada OA lutut. Mengetahui hubungan dan prevalensi antara DMT2 dan derajat keparahan OA lutut pada pasien Siloam Hospitals Lippo Village Paviliun B. Penelitian ini bersifat analitik komparatif kategorik tak berpasangan dengan desain studi potong lintang dengan total 131 sampel yang telah memenuhi kriteria inklusi dan eksklusi. Dari hasil penelitian ditemukan derajat keparahan OA lutut yang lebih tinggi pada pasien OA lutut dengan DMT2. Dari 35 sampel (100%) OA lutut dengan DMT2 didapatkan 23 pasien (65,7%) memiliki derajat berat dan 12 pasien (34,3%) memiliki derajat ringan. Dari 96 sampel (100%) OA lutut tanpa DMT2 didapatkan 55 pasien (57,3%) memiliki derajat ringan dan 41 pasien (42,7%) lainnya memiliki derajat berat. Terdapat hubungan yang signifikan antara DMT2 dengan derajat keparahan OA lutut pada pasien di Siloam Hospitals Lippo Village Paviliun B (n = 35, p-value 0,033). / Diabetes Mellitus (DM) is one of the common chronic diseases in society, affecting about 10% of the global population, and is characterized by elevated blood glucose levels. Osteoarthritis (OA) is the most common degenerative disease, characterized by the loss of cartilage, the formation of osteophytes, and synovitis. The knee joint is one of the joints most commonly affected. Both of these diseases are chronic and systemic conditions with low-grade inflammation, and they share similar risk factors. Individuals with diabetes mellitus have a higher incidence of osteoarthritis and a faster progression of the disease compared to individuals without diabetes. Several studies indicate that hyperglycemia contributes to joint damage in knee osteoarthritis. To understand the relationship and prevalence between type 2 diabetes mellitus (T2DM) and the severity of knee OA in patients at Siloam Hospitals Lippo Village Pavilion B. This study is a comparative analytical study of unmatched categorical design with a cross-sectional study design, involving a total of 131 samples that have met the inclusion and exclusion criteria. The study found a higher degree of severity of knee OA in patients with T2DM. Out of 35 samples (100%) of knee OA patients with T2DM, 23 patients (65.7%) had severe degrees, while 12 patients (34.3%) had mild degrees. In contrast, out of 96 samples (100%) of knee OA patients without T2DM, 55 patients (57.3%) had mild degrees, and 41 patients (42.7%) had severe degrees. There is a significant relationship between T2DM and the severity of Knee OA in patients at Siloam Hospitals Lippo Village Pavilion B (n = 35, p-value 0.033).
Item Type: | Thesis (Bachelor) |
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Creators: | Creators NIM Email ORCID Dion, Nathanael Orin NIM01071210145 orinodin@gmail.com UNSPECIFIED |
Contributors: | Contribution Contributors NIDN/NIDK Email Thesis advisor Siahaan, Yoseph Michael Putra Andreas NIDN20200081 yoseph.siahaan@uph.edu |
Uncontrolled Keywords: | diabetes melitus; DMT2; derajat keparahan; osteoartritis lutut |
Subjects: | R Medicine > R Medicine (General) |
Divisions: | University Subject > Current > Faculty/School - UPH Karawaci > Faculty of Medicine > Medicine Current > Faculty/School - UPH Karawaci > Faculty of Medicine > Medicine |
Depositing User: | NATHANAEL ORIN DION |
Date Deposited: | 06 Dec 2024 01:31 |
Last Modified: | 06 Dec 2024 01:31 |
URI: | http://repository.uph.edu/id/eprint/65674 |