Psychological Distress is a form of psychological issue that is prevalent amongst medical students. This issue emerges due to the heavy pressure that exists in that population, and as such, can disturb their livelihoods. Meaning in Life is found to be a protective factor for individuals in dealing with psychological issues. This research is done to examine the effects of Meaning in Life (Presence of Meaning & Search for Meaning) towards Psychological Distress (Depression, Anxiety, Stress). The participants that are included in this research are 111 first year medical students that currently study in the Jabodetabek area, they are recruited using purposive sampling. The instruments used in this research are Meaning in Life Questionnaire (MLQ) and DASS-21. While the research data is processed using PLS-SEM for nonparametric regression, and JASP for correlations amongst dimensions. The results from this research show that there is a significant effect from Presence of Meaning towards Depression, Anxiety, and Stress. On the other hand, Search for Meaning is found to have a significant effect towards Anxiety, but not towards Depression and Stress. From these findings, it can be concluded that the existence of meaning in life does affect the level of psychological distress of this specific population, while the search for meaning itself does not seem to affect psychological distress significantly, except for the feelings of anxiety. / Psychological Distress merupakan suatu permasalahan psikologis yang prevalen di antara kelompok mahasiswa fakultas kedokteran, permasalahan ini terjadi karena adanya tekanan yang besar pada populasi tersebut, dan hal ini dapat mengganggu kehidupan mereka. Kebermaknaan hidup ditemukan dapat menjadi suatu faktor protektif bagi individu dalam menghadapi permasalahan psikologis. Penelitian ini bertujuan untuk menelaah mengenai pengaruh Kebermaknaan Hidup (Presence of Meaning & Search for Meaning) terhadap Psychological Distress (Depression, Anxiety, Stress). Partisipan penelitian ini merupakan 111 mahasiswa fakultas kedokteran tahun pertama di Jabodetabek yang direkrut dengan teknik purposive sampling. Alat ukur yang digunakan adalah Meaning in Life Questionnaire (MLQ) dan DASS-21. Data penelitian diolah menggunakan PLS-SEM untuk regresi nonparametrik dan JASP untuk korelasi antar dimensi. Hasil dari penelitian menunjukkan bahwa terdapat pengaruh dari Presence of Meaning terhadap Depression, Anxiety, dan Stress. Sedangkan Search for Meaning ditemukan berpengaruh terhadap Anxiety, namun tidak terhadap Depression dan Stress. Hasil tersebut membuktikan bahwa keberadaan makna hidup berpengaruh terhadap psychological distress yang dimiliki pada populasi berikut, namun pencarian akan makna hidup tidak berpengaruh, kecuali terhadap kecemasan.