Tingginya urgensi inovasi di kalangan mahasiswa menuntut peran pendidikan kewirausahaan dalam menciptakan generasi yang kreatif dan solutif. Penelitian ini bertujuan untuk menganalisis pengaruh entrepreneurship education terhadap innovation dengan mempertimbangkan peran mediasi political skills dan entrepreneurial opportunity recognition. Sampel dalam penelitian ini terdiri dari 192 mahasiswa bisnis Universitas Katolik Parahyangan di Kota Bandung yang dipilih menggunakan teknik non-probability sampling, judgemental sampling. Metode analisis data yang digunakan adalah Partial Least Squares Structural Equation Modeling (PLS-SEM). Hasil penelitian menunjukkan bahwa entrepreneurship education berpengaruh positif terhadap innovation. Selain itu, political skills dan entrepreneurial opportunity recognition terbukti mampu menjadi mediator secara terpisah maupun secara bersamaan dalam memperkuat hubungan antara entrepreneurship education dan innovation. Temuan ini menegaskan pentingnya pendidikan kewirausahaan sebagai fondasi dalam membentuk pola pikir inovatif, serta peran political skills dan kemampuan mengenali peluang sebagai jembatan untuk mendorong terciptanya inovasi. / The increasing urgency for innovation among students demands the role of entrepreneurship education in shaping a creative and solution-oriented generation. This study aims to examine the influence of entrepreneurship education on innovation, considering the mediating roles of political skills and entrepreneurial opportunity recognition. The sample consists of 192 business students from Parahyangan Catholic University in Bandung, selected using non-probability, judgmental sampling techniques. Data were analyzed using Partial Least Squares Structural Equation Modeling (PLS-SEM). The results show that entrepreneurship education has a positive effect on innovation. Furthermore, political skills and entrepreneurial opportunity recognition are proven to mediate the relationship both individually and jointly. These findings highlight the importance of entrepreneurship education in fostering an innovative mindset, as well as the critical roles of political skills and opportunity recognition in driving innovation.