Pendahuluan: Mahasiswa, terutama keperawatan di asrama, rentan terhadap Gastroesophageal Reflux Disease (GERD) akibat padatnya tugas dan kegiatan yang berdampak pada kesehatan. Pencegahan GERD penting dilakukan melalui pengenalan gejala awal dengan self assessment GERD untuk menilai tanda, gejala, dan efektivitas pengobatan, diikuti penerapan praktik sehat. Penelitian ini bertujuan mengetahui hubungan antara self assessment GERD dengan praktik pencegahan GERD pada mahasiswa universitas swasta di Indonesia. Metode: Penelitian kuantitatif dengan desain cross-sectional melibatkan 735 mahasiswa. Sampel diambil menggunakan purposive sampling berdasarkan kriteria inklusi dan eksklusi. Data dikumpulkan melalui GERD Questionnaire (GERD-Q) untuk self assessment GERD dan kuesioner praktik pencegahan GERD. Analisis data menggunakan univariat dan bivariat dengan uji Chi-square. Hasil dan Kesimpulan: Mayoritas mahasiswa berusia 19-21 tahun dan didominasi perempuan (89,1%). Sebagian besar mahasiswa menunjukkan hasil self assessment GERD negatif (83,9%) dan praktik pencegahan GERD yang negatif (69,8%). Uji Chi-square menunjukkan tidak terdapat hubungan signifikan antara self assessment GERD dengan praktik pencegahan GERD (p = 0,509). Hasil ini mengindikasikan bahwa praktik pencegahan yang kurang baik tidak secara langsung memicu gejala GERD pada populasi ini. Rekomendasi: Penelitian lebih lanjut diperlukan unutk mengidentifikasi faktor-faktor spesifik yang mempengaruhi gejala GERD dan pratik pencegahan GERD pada mahasiswa. / Background: Gastroesophageal Reflux Disease (GERD) is prevalent among university students, particularly nursing students in dormitories who face elevated risk due to demanding academics and activities impacting health. Early symptom recognition via GERD self-assessment using the GERD Questionnaire (GERD-Q) is crucial for prevention and evaluating medication effectiveness, enabling students to adopt healthy practices. Objective: This study examined the relationship between GERD self-assessment and prevention practices among students at a private Indonesian university. Methods: A quantitative cross-sectional design involving 735 students was used. Purposive sampling based on criteria was applied. Data were collected using the GERD-Q and a prevention practices questionnaire, analyzed with univariate and bivariate methods, and Chi-square tests. Results: Most students were aged 19–21 and predominantly female (89.1%). The majority showed negative GERD self-assessment (83.9%) and poor prevention practices (69.8%). The Chi-square test revealed no significant relationship between self-assessment and prevention practices (p = 0.509), suggesting poor practices did not directly trigger GERD in this population. Recommendation: Further research is needed to identify specific factors influencing GERD symptoms and prevention practices in students.