Latar Belakang: Keputihan adalah keluarnya cairan putih dari vagina yang bersifat fisiologis, namun jika kebersihan tidak dijaga, dapat berubah menjadi patologis. Di Indonesia, prevalensi keputihan patologis pada remaja putri mencapai 90%. Wawancara terhadap 20 mahasiswi di Tangerang menunjukkan 100% pernah mengalami keputihan, 75% dengan ciri menggumpal seperti tepung dan berwarna putih pekat, serta 80% tidak mampu membedakan antara keputihan fisiologis dan patologis. Tujuan: Mengetahui hubungan antara pengetahuan dan sikap tentang vulva hygiene terhadap kejadian keputihan pada mahasiswi di salah satu universitas swasta di Tangerang. Metode penelitian: Penelitian kuantitatif dengan desain cross-sectional. Sampel sebanyak 219 mahasiswi diperoleh melalui purposive sampling. Instrumen menggunakan kuesioner yang telah diuji validitas dan reliabilitasnya. Analisis data mencakup univariat dan bivariat. Hasil: Sebanyak 91,8% responden memiliki pengetahuan baik, 50,7% memiliki sikap positif, dan 81,7% mengalami keputihan normal. Tidak terdapat hubungan signifikan antara pengetahuan (p=0,108) dan sikap (p=0,656) dengan kejadian keputihan. Kesimpulan: Pengetahuan dan sikap mengenai vulva hygiene tidak memiliki hubungan terhadap kejadian keputihan. Artinya, pengetahuan dan sikap yang baik tidak secara langsung mencegah keputihan. Penelitian selanjutnya disarankan mengeksplorasi faktor lain yang berpotensi memengaruhi hubungan kejadian keputihan. / Background: Vaginal discharge is a physiological condition that can become pathological if hygiene is neglected. In Indonesia, 90% of adolescent girls experience pathological discharge. Interviews with students in Tangerang showed 100% had experienced discharge, with 75% showing abnormal characteristics and 80% unable to distinguish between physiological and pathological types. Objective: To examine the relationship between vulva hygiene knowledge and attitudes with the incidence of vaginal discharge among female students at a private university in Tangerang. Research Methods: A cross-sectional quantitative study involving 219 purposively selected female students. A validated and reliable questionnaire was used, and data were analyzed using univariate and bivariate. Results: A total of 91.8% of respondents had good knowledge, 50.7% had a positive attitude, and 81.7% experienced normal vaginal discharge. There was no significant relationship between knowledge (p=0.108) and attitude (p=0.656) with the incidence of vaginal discharge. Conclusion: Knowledge and attitudes regarding vulva hygiene have no relationship to the incidence of vaginal discharge. This means that good knowledge and attitudes do not directly prevent vaginal discharge. Future research is recommended to explore other factors that may potentially influence the occurrence of vaginal discharge.