Uji aktivitas antihiperglikemia ekstrak biji melon(Cucumis melo L.)pad mencit (Mus musculus) = Test antihyperglycemic activity of meloon seeds extracts (Cucumis melo L.) in mice (Mus musculus)

Sutejo, Aurelia Gabrielle (2022) Uji aktivitas antihiperglikemia ekstrak biji melon(Cucumis melo L.)pad mencit (Mus musculus) = Test antihyperglycemic activity of meloon seeds extracts (Cucumis melo L.) in mice (Mus musculus). Diploma thesis, Universitas Pelita Harapan.

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Abstract

Diabetes melitus di Indonesia sudah mencapai angka 19,5 juta penderita yang menempatkan Indonesia pada posisi kelima di dunia dengan jumlah penderita diabetes melitus terbanyak pada tahun 2021. Diabetes melitus merupakan penyakit yang ditandai dengan adanya hiperglikemia dan dalam pengobatannya terdapat beberapa efek samping yang berbahaya. Oleh karena itu, dikembangkan pengobatan alternatif dari tumbuhan, khususnya yang mengandung flavonoid seperti biji melon (Cucumis melo L.). Ekstrak biji melon yang telah dimaserasi menggunakan etanol 70% dan diujikan ke mencit (Mus musculus) yang telah diinduksi glukosa dengan dosis 50 mg/20g BB, 100 mg/20g BB, dan 150 mg/20g BB secara oral dan dengan pembanding metformin. Ekstrak etanol 70% biji melon mengandung senyawa aktif, yaitu flavonoid, alkaloid, tanin, dan terpenoid. Ekstrak etanol biji melon secara signifikan dapat menurunkan kadar glukosa darah dengan dosis 50 mg/20gBB, 100 mg/20gBB, dan 150 mg/20gBB dengan dosis penurunan paling besar adalah 100 mg/20gBB. / Diabetes mellitus in Indonesia has reached 19.5 million sufferers which puts Indonesia in fifth position in the world with the highest number of people with diabetes mellitus in 2021. Diabetes mellitus is a disease characterized by hyperglycemia and in its treatment there are several dangerous side effects. Therefore, alternative medicine from plants has been developed, especially those containing flavonoids such as melon seeds (Cucumis melo L.). The melon seed extract which had been macerated using 70% ethanol and was tested on mice (Mus musculus) which had been induced by glucose at a dose of 50 mg/20g BW, 100 mg/20g BW, and 150 mg/20g BW orally and with a comparison of metformin. The 70% ethanol extract of melon seeds contained active compounds, namely flavonoids, alkaloids, tannins, and terpenoids. Melon seed ethanol extract could significantly reduce blood glucose levels with dose of 50 mg/20gBW, 100 mg/20g BW, 150 mg/20gBW with the greatest decreasing dose is 100 mg/20gBW.

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