Formulasi dan uji aktivitas ekstrak pacar kuku (Lawsonia inermis L.) sebagai cat kuku anti mikotik

Joscelline, Natasya (2024) Formulasi dan uji aktivitas ekstrak pacar kuku (Lawsonia inermis L.) sebagai cat kuku anti mikotik. Bachelor thesis, Universitas Pelita Harapan.

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Abstract

Daun Lawsonia inermis L. memiliki kandungan Lawsone (2-hidroksi-1:4 naftakuinon) yang memiliki khasiat antijamur terhadap Trichophyton rubrum dan Trichophyton mentagrophytes. Kedua jamur ini dapat menginfeksi kuku yang dikenal dengan penyakit Tinea unguium. Salah satu sistem penghantaran pada pengobatan antijamur adalah transungual drug delivery, penghantaran obat secara topikal melalui pernis kuku (cat kuku) anti mikotik. Penelitian ini bertujuan untuk melihat potensi ekstrak etanol 96% Lawsonia inermis L. sebagai antijamur dan sekaligus dapat memberikan warna pada kuku. Metode ekstraksi yang digunakan adalah maserasi dengan pelarut etanol 96%. Pengujian aktivitas antijamur ekstrak digunakan metode difusi sumur dengan konsentrasi yang berbeda. Penentuan aktivitas antijamurnya dinyatakan dalam zona hambat yang terbentuk. Optimasi formulasi dengan perbandingan konsentrasi ekstrak dan konsentrasi polivinil pirolidon sebagai polimer untuk mendapatkan formula optimum terhadap potensi antijamur. Konsentrasi ekstrak yang diambil dalam formulasi yaitu 15% dan hasil formulasi berdasarkan analisa data pada polimer polivinil pirolidon yang baik pada formulasi I dan III, tetapi pada keefektivan sediaan sebagai anti jamur maka formula V lebih baik karena memiliki zona hambat yang luas dan formulasi V juga telah memenuhi semua rentang syarat evaluasi sediaan lainnya. / Lawsonia inermis L. leaves contain Lawsone (2-hydroxy-1:4 naphthakuinone) which has antifungal properties against Trichophyton rubrum and Trichophyton mentagrophytes. Both of these fungi can infect the nail, known as Tinea unguium. One of the delivery systems in antifungal treatment is transungual drug delivery, topical drug delivery through anti-mycotic nail varnish (nail polish). This study aims to see the potential of 96% ethanol extract of Lawsonia inermis L. as an antifungal and at the same time can provide color to the nails. The extraction method used was maceration with 96% ethanol solvent. Testing the antifungal activity of the extract used well diffusion method with different concentrations. Determination of antifungal activity is expressed in the zone of inhibition formed. Formulation optimization with the ratio of extract concentration and polyvinyl pyrrolidone concentration as a polymer to obtain the optimum formula for antifungal potential. The concentration of extract taken in the formulation is 15% and the results of the formulation based on data analysis on polyvinyl pyrrolidone polymers are good in formulations I and III, but in the effectiveness of the drug preparation as an anti-fungal, formula V is better because it has a wide zone of inhibition and formulation V has also fulfilled all other range of formulation evaluation requirements.

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