Stres kerja merupakan suatu kondisi fisik dan emosional yang terjadi ketika pekerjaan yang dilakukan tidak sesuai dengan kemampuan pekerja. Stres kerja memiliki dampak negatif meliputi gejala fisik dan gejala psikologis yang dapat menyebabkan terjadinya kesalahan saat melakukan perawatan. Tujuan penelitian untuk mengetahui gambaran tingkat stres kerja pada perawat di ruang In Patient Department (IPD) 1 & 2 di Satu Rumah Sakit Swasta Indonesia Bagian Tengah. Penelitian ini menggunakan desain penelitian deskriptif kuantitatif. Jenis penentuan sampel menggunakan metode total sampling. Instrumen penelitian ini menggunakan kuesioner Stres Kerja yang diadaptasi dari Nursalam (2003) berisi 50 pertanyaan. Analisa data menggunakan analisis univariat. Hasil penelitian menunjukan sebanyak (76.47%) mengalami stres kerja ringan dan sebanyak (23.53%) mengalami stres kerja sedang, sedangkan berdasarkan karakteristik responden yang mempunyai stres kerja tertingi adalah kelompok usia 26-30 tahun, tingkat pendidikan SI Keperawatan/Ners, dan lama masa kerja 2-3 tahun. Sebagian besar perawat di ruang In Patient Department (IPD) 1 & 2 di Satu Rumah Sakit Swasta Indonesia Bagian Tengah mengalami stres kerja tingkat ringan. Penelitian selanjutnya perlu mengembangkan penelitian ini dengan menambahkan kategori tingkat stres menjadi wellness, stres ringan, stres sedang, stres berat hingga panic = Work stress is a physical and emotional condition that occurs when work is done not in accordance with the ability of workers. Work stress has a negative impact including physical symptoms and psychological symptoms that can cause errors during treatment. The purpose of this study was to find out the description of work stress level on nurses in In Patient Department (IPD) 1 & 2 In The Central Indonesian Private Hospital House. This research will use descriptive research design of quantitative (Descriptive Research). Type of sampling of this research using total sampling method. Instruments in this study using questionaire containing 50 questions. The data analysis uses univariate analysis. The results of this study showed that (76.47%) had mild work stress and (23.53%) had moderate work stress, where as based on respondent characteristics that had the highest work stress were 26-30 years old, Bachelor of Nursing level, and duration of 2-3 years. Most nurses in the In Patient Department (IPD) 1 & 2 In The Central Indonesian Private Hospital House are experiencing mild-level work stress. Resercher recommend for future research needs to develop this research by adding categories of stress levels to wellness, mild stress, moderate stress, severe stress to panic.