Latar Belakang: Perkembangan Ilmu Pengetahuan dan Teknologi (IPTEK) dewasa ini menyebabkan adanya perubahan khususnya dalam metode pembelajaran, yaitu peralihan dari metode konvensional menjadi metode pembelajaran online. E-learning adalah kegiatan belajar mengajar yang dilakukan secara online dengan memanfaatkan teknologi informasi dan jaringan dengan jarak jauh. Persepsi merupakan sebuah nilai dari proses belajar atau pengalaman individu atas apa yang di terima, diproses, dan diinterpertasikan lewat sikap ataupun perilaku. Tujuan Penelitian: untuk mengetahui gambaran persepsi mahasiswa tentang keefektifan e-learning dalam proses pembelajaran di satu Universitas Swasta Indonesia bagian Barat. Metode Penelitian: Peneliti menggunakan metode penelitian kuantitatif deskriptif dengan pendekatan cross sectional dengan sampel sebanyak 183 orang. Instrumen yang digunakan adalah kuesioner skala likert tentang keefektifan e-learning. Pengambilan sampel menggunakan probability sampling yaitu kategori simple random sampling. Hasil: Hasil analisis univariat tentang keefektifan e-learning yang paling banyak adalah baik sebanyak 88% (161 responden), dan hasil platform e-learning yang paling banyak digunakan adalah Moodle, Zoom, dan Ms. Teams. Hal ini menunjukan bahwa persepsi mahasiswa keperawatan di satu universitas swasta terhadap keefektifan e-learning adalah baik. Rekomendasi: Bagi peneliti selanjutnya dapat membahas tentang faktor yang mempengaruhi persepsi mahasiswa terhadap keefektifan e-learning dan menghubungkannya dengan keperawatan seperti kecerdasan intelektual, minat dan metode pembelajaran dalam hal keefektifan e-learning / Background: The development of Science and Technology nowadays cause changes especially in learning methods, that is the transition from conventional methods to online learning methods. E-learning is an online teaching and learning activity by utilizing information technology and networks. Perception is a value from the learning process or individual experience of what is received, processed, and interpreted through attitudes or behaviour. Research Objectives: to determine the description of student perceptions about the of effectiveness of e-learning in the learning process at a western part of Indonesia's private university. Methods: Researchers used descriptive quantitative research methods with cross sectional approach with a sample of 183 people. The instrument that used was a Likert scale questionnaire about the of effectiveness of e-learning. Sampling was used probability sampling, namely categorical simple random sampling. Results: The results of the univariate analysis of the of effectiveness of e-learning were mostly good as many as 88% (161 respondents), and the results of the most widely used e-learning platforms were Moodle, Zoom, and Ms. Teams. This shows that the perception of nursing students at a private university on the of effectiveness of e-learning is good. Recommendation: For further researchers, it can discuss the factors that influence student perceptions of the of effectiveness of e-learning and relate them to nursing such as intellectual intelligence, interests and learning methods in terms of e-learning of effectiveness.