Putri, Anatasia Denisa Natalia (2022) Uji efek antihiperlipidemia ekstrak etanol 70% daun Ketul (Bidens pilosa L.) terhadap mencit (Mus musculus). Diploma thesis, Universitas Pelita Harapan.
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Abstract
Kasus penyakit hiperlipidemia setiap tahunnya dapat membunuh hingga 71%
penduduk dunia dan kasusnya terus mengalami peningkatan, terutama pada usia
produktif. Pada penelitian sebelumnya didapatkan, bahwa biji Ketul dapat
menurunkan kolesterol dengan meningkatkan jumlah HDL dan juga pada daun
Ketul memiliki efek antioksidan yang dapat mengurangi oksidasi asam lemak. Oleh
karena itu, dilakukan penelitian uji efek antihiperlipidemia dari daun Ketul untuk
mengetahui apakah daun Ketul memiliki efek antihiperlipidemia atau tidak dan
mengetahui dosis ekstrak daun Ketul yang efektif untuk antihiperlipidemia, serta
metabolit sekunder yang terkandung dalam daun Ketul. Ekstrak daun Ketul dibuat
dengan metode refluks menggunakan pelarut etanol 70%. Uji antihiperlipidemia
dilakukan terhadap mencit yang dibagi menjadi 5 kelompok. Kelomopk I diberi
CMC Na 0,5%; Kelompok II diberi Simvastatin 0,052 mg/gBB mencit, Kelompok
III, IV, dan V diberi ekstrak (100, 300, 500 mg/kgBB). Setiap kelompok diinduksi
dengan makanan tinggi lemak dan PTU 0,02% selama seminggu, kemudian
diberikan ekstrak selama 2 minggu. Kadar kolesterol total mencit dicek setiap sekali
seminggu. Efek penurunan kolesterol mencit diketahui dari hasil perhitungan
persentase penurunan dan uji analisis menggunakan One-Way ANOVA.
Berdasarkan hasil analisis One-Way ANOVA didapatkan bahwa ekstrak etanol
70% daun Ketul memiliki efek antihiperlipidemia dengan dosis yang efektif adalah
100 mg/kgBB/./Cases of hyperlipidemic each year can kill up to 71% of the world population and
continue to increase, especially in productive age. A previous study found that Ketul
seeds can lower total cholesterol by increasing the amount of HDL. Ketul leaves
have an antioxidant effect that can reduce fatty acid oxidation. Therefore, a study
about the antihyperlipidemic effect of Ketul leaves is conducted, to determine the
effective dose for Ketul leaf extract as antihyperlipidemic, also to know secondary
metabolites contained in Ketul leaves. Ketul leaf extract was made by reflux using
70% ethanol as solvent. An antihyperlipidemic test that performed on mice and
divided into five groups. Group I given CMC Na 0.5%; Group II given Simvastatin
0.052 mg/20gBW mice, Group III, IV, and V given extract (100, 300, 500 mg/kg
BW). Each group was induced with a high-fat diet and 0.02% PTU for a week, then
given the extract for two weeks. The mice's total cholesterol levels were checked
once a week. The effect of reducing cholesterol in mice is known by calculating the
percentage reduction and analysis using One-Way ANOVA. The result of this
research is that 70% ethanol extract of Ketul leaves has an antihyperlipidemic
effect with an effective dose of 100 mg/kg BW.
Item Type: | Thesis (Diploma) |
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Creators: | Creators NIM Email ORCID Putri, Anatasia Denisa Natalia NIM011741900002 denisanatalia17@gmail.com UNSPECIFIED |
Contributors: | Contribution Contributors NIDN/NIDK Email UNSPECIFIED Riskianto, Riskianto NIDN20190150 UNSPECIFIED |
Uncontrolled Keywords: | antihiperlipidemia, daun ketul (Bidens pilosa L.), refluks, makanan tinggi lemak, PTU 0.02%, kolesterol total, mencit (Mus musculus) |
Subjects: | R Medicine > RS Pharmacy and materia medica |
Divisions: | University Subject > Current > Faculty/School - UPH Karawaci > Faculty of Health Sciences > Pharmacy (Diploma) Current > Faculty/School - UPH Karawaci > Faculty of Health Sciences > Pharmacy (Diploma) |
Depositing User: | Anatasia Denisa Natalia Putri |
Date Deposited: | 08 Sep 2022 03:05 |
Last Modified: | 08 Sep 2022 03:05 |
URI: | http://repository.uph.edu/id/eprint/50288 |